ATP5G2

Protein-coding gene in humans
ATP5MC2
Identifiers
AliasesATP5MC2, ATP5A, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9), ATP synthase membrane subunit c locus 2, ATP5G2
External IDsOMIM: 603193; MGI: 1915192; HomoloGene: 57052; GeneCards: ATP5MC2; OMA:ATP5MC2 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for ATP5MC2
Genomic location for ATP5MC2
Band12q13.13Start53,632,726 bp[1]
End53,677,408 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for ATP5MC2
Genomic location for ATP5MC2
Band15|15 F3Start102,571,299 bp[2]
End102,580,787 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • islet of Langerhans

  • right uterine tube

  • anterior pituitary

  • body of stomach

  • embryo

  • right adrenal gland

  • ganglionic eminence

  • left ventricle

  • body of pancreas
Top expressed in
  • embryo

  • quadriceps femoris muscle

  • neural tube

  • stomach

  • esophagus

  • yolk sac

  • proximal tubule

  • blastocyst

  • mesencephalon

  • ganglionic eminence
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • proton transmembrane transporter activity
  • lipid binding
  • transporter activity
  • proton-transporting ATP synthase activity, rotational mechanism
  • protein binding
Cellular component
  • proton-transporting ATP synthase complex, coupling factor F(o)
  • integral component of membrane
  • mitochondrial outer membrane
  • proton-transporting two-sector ATPase complex, proton-transporting domain
  • mitochondrial proton-transporting ATP synthase complex
  • membrane
  • mitochondrion
  • mitochondrial membranes
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
Biological process
  • ion transport
  • ATP biosynthetic process
  • ATP synthesis coupled proton transport
  • cristae formation
  • mitochondrial ATP synthesis coupled proton transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

517

67942

Ensembl

ENSG00000135390

ENSMUSG00000062683

UniProt

Q06055

P56383

RefSeq (mRNA)

NM_001002031
NM_005176
NM_001330269

NM_026468

RefSeq (protein)
NP_001002031
NP_001317198
NP_005167
NP_001356682
NP_001356683

NP_001356684
NP_001356685
NP_001356686
NP_001356687

NP_080744

Location (UCSC)Chr 12: 53.63 – 53.68 MbChr 15: 102.57 – 102.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The ATP5MC2 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.[5][6]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135390 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062683 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dyer MR, Walker JE (Aug 1993). "Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase". Biochem J. 293 (1): 51–64. doi:10.1042/bj2930051. PMC 1134319. PMID 8328972.
  6. ^ a b "Entrez Gene: ATP5MC2 ATP synthase membrane subunit c locus 2".

External links

Further reading

  • Farrell LB, Nagley P (1987). "Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex". Biochem. Biophys. Res. Commun. 144 (3): 1257–64. doi:10.1016/0006-291X(87)91446-X. PMID 2883974.
  • Yan WL, Lerner TJ, Haines JL, Gusella JF (1995). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3)". Genomics. 24 (2): 375–7. doi:10.1006/geno.1994.1631. PMID 7698763.
  • Houstĕk J, Andersson U, Tvrdík P, et al. (1995). "The expression of subunit c correlates with and thus may limit the biosynthesis of the mitochondrial F0F1-ATPase in brown adipose tissue". J. Biol. Chem. 270 (13): 7689–94. doi:10.1074/jbc.270.13.7689. PMID 7706317.
  • Higuti T, Kawamura Y, Kuroiwa K, et al. (1993). "Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria". Biochim. Biophys. Acta. 1173 (1): 87–90. doi:10.1016/0167-4781(93)90249-D. PMID 8485160.
  • Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. Bibcode:1998Natur.391..510E. doi:10.1038/35185. PMID 9461222. S2CID 4406161.
  • Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. Bibcode:1998Natur.396..279W. doi:10.1038/24409. PMID 9834036. S2CID 4424498.
  • Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cross RL (2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. Bibcode:2004Natur.427..407C. doi:10.1038/427407b. PMID 14749816. S2CID 52819856.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.


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