ATP5S

Protein-coding gene in the species Homo sapiens
DMAC2L
Identifiers
AliasesDMAC2L, ATPW, FB, HSU79253, ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B), ATP5S, distal membrane arm assembly complex 2 like, distal membrane arm assembly component 2 like
External IDsMGI: 1915305 HomoloGene: 12232 GeneCards: DMAC2L
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for DMAC2L
Genomic location for DMAC2L
Band14q21.3Start50,312,324 bp[1]
End50,335,558 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for DMAC2L
Genomic location for DMAC2L
Band12|12 C2Start69,771,724 bp[2]
End69,791,434 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • right uterine tube

  • endothelial cell

  • triceps brachii muscle

  • oocyte

  • thoracic diaphragm

  • right ventricle

  • human penis

  • muscle of leg

  • gastrocnemius muscle
Top expressed in
  • interventricular septum

  • spermatid

  • right ventricle

  • spermatocyte

  • sternocleidomastoid muscle

  • digastric muscle

  • myocardium of ventricle

  • triceps brachii muscle

  • temporal muscle

  • proximal tubule
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • proton transmembrane transporter activity
  • metal ion binding
Cellular component
  • mitochondrion
  • membrane
  • proton-transporting ATP synthase complex, coupling factor F(o)
  • mitochondrial inner membrane
Biological process
  • ion transport
  • ATP biosynthetic process
  • cristae formation
  • proton transmembrane transport
  • mitochondrial ATP synthesis coupled proton transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27109

68055

Ensembl

ENSG00000125375

ENSMUSG00000054894

UniProt

Q99766

Q9CRA7

RefSeq (mRNA)
NM_001003803
NM_001003805
NM_015684
NM_001370605
NM_001382507

NM_001382509
NM_001382510

NM_026536
NM_001361690
NM_001361691

RefSeq (protein)
NP_001003803
NP_001003805
NP_056499
NP_001357534
NP_001369436

NP_001369438
NP_001369439

NP_080812
NP_001348619
NP_001348620

Location (UCSC)Chr 14: 50.31 – 50.34 MbChr 12: 69.77 – 69.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP synthase subunit s, mitochondrial is an enzyme that in humans is encoded by the ATP5S gene.[5][6][7]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125375 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054894 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Belogrudov GI, Hatefi Y (Feb 2002). "Factor B and the mitochondrial ATP synthase complex". J Biol Chem. 277 (8): 6097–103. doi:10.1074/jbc.M111256200. PMID 11744738.
  6. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  7. ^ a b "Entrez Gene: ATP5S ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)".

External links

  • Human ATP5S genome location and ATP5S gene details page in the UCSC Genome Browser.
  • ATP5S: ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)

Further reading

  • Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine". Essays Biochem. 35: 3–18. doi:10.1042/bse0350003. PMID 12471886.
  • Oster G, Wang H (2003). "Rotary protein motors". Trends Cell Biol. 13 (3): 114–21. doi:10.1016/S0962-8924(03)00004-7. PMID 12628343.
  • Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)". Mol. Membr. Biol. 20 (1): 27–33. doi:10.1080/0968768031000066532. PMID 12745923. S2CID 218895820.
  • Sanadi DR, Pringle M, Kantham L, et al. (1984). "Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase". Proc. Natl. Acad. Sci. U.S.A. 81 (5): 1371–4. Bibcode:1984PNAS...81.1371S. doi:10.1073/pnas.81.5.1371. PMC 344835. PMID 6143319.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. Bibcode:1998Natur.391..510E. doi:10.1038/35185. PMID 9461222. S2CID 4406161.
  • Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. Bibcode:1998Natur.396..279W. doi:10.1038/24409. PMID 9834036. S2CID 4424498.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cross RL (2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. Bibcode:2004Natur.427..407C. doi:10.1038/427407b. PMID 14749816.
  • Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.


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