ATP9A

Protein-coding gene in the species Homo sapiens
ATP9A
Identifiers
AliasesATP9A, ATPIIA, ATPase phospholipid transporting 9A (putative)
External IDsOMIM: 609126 MGI: 1330826 HomoloGene: 69194 GeneCards: ATP9A
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for ATP9A
Genomic location for ATP9A
Band20q13.2Start51,596,514 bp[1]
End51,768,390 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for ATP9A
Genomic location for ATP9A
Band2|2 H3Start168,476,358 bp[2]
End168,584,329 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • Brodmann area 46

  • Brodmann area 23

  • orbitofrontal cortex

  • internal globus pallidus

  • entorhinal cortex

  • superior frontal gyrus

  • postcentral gyrus

  • Brodmann area 10

  • frontal pole
Top expressed in
  • entorhinal cortex

  • superior frontal gyrus

  • cerebellar cortex

  • dorsomedial hypothalamic nucleus

  • primary motor cortex

  • superior colliculus

  • prefrontal cortex

  • subiculum

  • pons

  • facial motor nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ATPase-coupled intramembrane lipid transporter activity
  • nucleotide binding
  • ATP binding
  • magnesium ion binding
  • hydrolase activity
  • metal ion binding
Cellular component
  • perinuclear region of cytoplasm
  • integral component of membrane
  • recycling endosome
  • endosome
  • trans-Golgi network
  • plasma membrane
  • Golgi apparatus
  • early endosome
  • early endosome membrane
  • membrane
Biological process
  • phospholipid transport
  • endocytosis
  • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
  • phospholipid translocation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10079

11981

Ensembl

ENSG00000054793

ENSMUSG00000027546

UniProt

O75110

O70228

RefSeq (mRNA)

NM_006045

NM_001289445
NM_001289446
NM_015731
NM_001354977
NM_001354978

RefSeq (protein)

NP_006036

NP_001276374
NP_001276375
NP_056546
NP_001341906
NP_001341907

Location (UCSC)Chr 20: 51.6 – 51.77 MbChr 2: 168.48 – 168.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable phospholipid-transporting ATPase IIA is a protein that in humans is encoded by the ATP9A gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000054793 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027546 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "ATP9A - Probable phospholipid-transporting ATPase IIA - Homo sapiens (Human) - ATP9A gene & protein". www.uniprot.org. Retrieved 9 April 2022.
  6. ^ "Entrez Gene: ATPase phospholipid transporting 9A (putative)". Retrieved 2016-10-04.

Further reading

  • Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C (2008). "Molecular genetics of successful smoking cessation: convergent genome-wide association study results". Arch. Gen. Psychiatry. 65 (6): 683–93. doi:10.1001/archpsyc.65.6.683. PMC 2430596. PMID 18519826.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.


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