Aminomuconate-semialdehyde dehydrogenase

aminomuconate-semialdehyde dehydrogenase
aminomuconate-semialdehyde dehydrogenase tetramer, Pseudomonas
Identifiers
EC no.	1.2.1.32
CAS no.	37250-95-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an aminomuconate-semialdehyde dehydrogenase (EC 1.2.1.32) is an enzyme that catalyzes the chemical reaction

2-aminomuconate 6-semialdehyde + NAD⁺ + H₂O ${\displaystyle \rightleftharpoons }$ 2-aminomuconate + NADH + 2 H⁺

The 3 substrates of this enzyme are 2-aminomuconate 6-semialdehyde, NAD⁺, and H₂O, whereas its 3 products are 2-aminomuconate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in 3 metabolic pathways: benzoic acid degradation via hydroxylation, tryptophan metabolism, and the degradation pathway for toluene and xylene.

Nomenclature

The systematic name of this enzyme class is 2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase. Other names in common use include 2-aminomuconate semialdehyde dehydrogenase, 2-hydroxymuconic acid semialdehyde dehydrogenase, 2-hydroxymuconate semialdehyde dehydrogenase, alpha-aminomuconic epsilon-semialdehyde dehydrogenase, alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase, and 2-hydroxymuconic semialdehyde dehydrogenase.

References

Further reading