CEP164

Protein-coding gene in the species Homo sapiens
CEP164
Identifiers
AliasesCEP164, NPHP15, centrosomal protein 164
External IDsOMIM: 614848; MGI: 2384878; HomoloGene: 51110; GeneCards: CEP164; OMA:CEP164 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CEP164
Genomic location for CEP164
Band11q23.3Start117,314,557 bp[1]
End117,413,266 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for CEP164
Genomic location for CEP164
Band9|9 A5.2Start45,678,244 bp[2]
End45,739,989 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • sural nerve

  • nipple

  • right uterine tube

  • bronchial epithelial cell

  • visceral pleura

  • parietal pleura

  • pylorus

  • Brodmann area 23

  • internal globus pallidus
Top expressed in
  • secondary oocyte

  • internal carotid artery

  • spermatid

  • external carotid artery

  • ureter

  • spermatocyte

  • hand

  • seminiferous tubule

  • superior cervical ganglion

  • medullary collecting duct
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • ciliary transition fiber
  • cytoplasm
  • centriole
  • cytosol
  • centrosome
  • cytoskeleton
  • nucleus
  • nucleoplasm
  • extracellular space
  • nuclear speck
  • intracellular membrane-bounded organelle
Biological process
  • cell division
  • cell cycle
  • cell projection organization
  • G2/M transition of mitotic cell cycle
  • DNA repair
  • cellular response to DNA damage stimulus
  • cilium assembly
  • ciliary basal body-plasma membrane docking
  • regulation of G2/M transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22897

214552

Ensembl

ENSG00000110274

ENSMUSG00000043987

UniProt

Q9UPV0

Q5DU05

RefSeq (mRNA)

NM_001271933
NM_014956

NM_001081373

RefSeq (protein)

NP_001258862
NP_055771

n/a

Location (UCSC)Chr 11: 117.31 – 117.41 MbChr 9: 45.68 – 45.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene.[5][6] Its function appears two be twofold: CEP164 is required for primary cilium formation.[7] Furthermore, it is an important component in the response to DNA damage by UV light.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110274 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043987 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: centrosomal protein 164kDa".
  6. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
  7. ^ Graser, S.; Stierhof, Y. -D.; Lavoie, S. B.; Gassner, O. S.; Lamla, S.; Le Clech, M.; Nigg, E. A. (2007). "Cep164, a novel centriole appendage protein required for primary cilium formation". The Journal of Cell Biology. 179 (2): 321–30. doi:10.1083/jcb.200707181. PMC 2064767. PMID 17954613.
  8. ^ Sivasubramaniam, S.; Sun, X.; Pan, Y. -R.; Wang, S.; Lee, E. Y. -H. P. (2008). "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1". Genes & Development. 22 (5): 587–600. doi:10.1101/gad.1627708. PMC 2259029. PMID 18283122.
  9. ^ Pan, YR; Lee, EY (2009). "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity". Cell Cycle. 8 (4): 655–64. doi:10.4161/cc.8.4.7844. PMID 19197159.

External links

Further reading

  • Graser S, Stierhof YD, Lavoie SB, et al. (2007). "Cep164, a novel centriole appendage protein required for primary cilium formation". J. Cell Biol. 179 (2): 321–30. doi:10.1083/jcb.200707181. PMC 2064767. PMID 17954613.
  • Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". J. Cell Biol. 129 (6): 1617–28. doi:10.1083/jcb.129.6.1617. PMC 2291169. PMID 7790358.
  • Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell. 5 (1): 113–25. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Mayor T, Stierhof YD, Tanaka K, et al. (2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837–46. doi:10.1083/jcb.151.4.837. PMC 2169446. PMID 11076968.
  • Sivasubramaniam S, Sun X, Pan YR, et al. (2008). "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1". Genes Dev. 22 (5): 587–600. doi:10.1101/gad.1627708. PMC 2259029. PMID 18283122.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Petretti C, Savoian M, Montembault E, et al. (2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation". EMBO Rep. 7 (4): 418–24. doi:10.1038/sj.embor.7400639. PMC 1456919. PMID 16462731.
  • Zick A, Onn I, Bezalel R, et al. (2005). "Assigning functions to genes: identification of S-phase expressed genes in Leishmania major based on post-transcriptional control elements". Nucleic Acids Res. 33 (13): 4235–42. doi:10.1093/nar/gki742. PMC 1181863. PMID 16052032.
  • Pan YR, Lee EY (2009). "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity". Cell Cycle. 8 (4): 655–64. doi:10.4161/cc.8.4.7844. PMID 19197159.
  • Takahashi M, Yamagiwa A, Nishimura T, et al. (2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.


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