CHST2

Protein-coding gene in the species Homo sapiens

CHST2

Identifiers

Aliases

CHST2, C6ST, GST-2, GST2, Gn6ST-1, HEL-S-75, glcNAc6ST-1, carbohydrate sulfotransferase 2

External IDs

OMIM: 603798; MGI: 1891160; HomoloGene: 3150; GeneCards: CHST2; OMA:CHST2 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q24	Start	143,119,771 bp^[1]
Band	3q24	End	143,124,014 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 E3.3	Start	95,281,345 bp^[2]
Band	9\|9 E3.3	End	95,288,775 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

decidua

lateral nuclear group of thalamus

hair follicle

trabecular bone

cartilage tissue

spinal cord

C1 segment

olfactory bulb

granulocyte

subthalamic nucleus

Top expressed in

supraoptic nucleus

olfactory tubercle

habenula

ascending aorta

medial geniculate nucleus

aortic valve

subiculum

lateral septal nucleus

lateral geniculate nucleus

medial dorsal nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity sulfotransferase activity N-acetylglucosamine 6-O-sulfotransferase activity
Cellular component	integral component of membrane Golgi membrane trans-Golgi network intrinsic component of Golgi membrane membrane Golgi apparatus
Biological process	multicellular organism development sulfur compound metabolic process inflammatory response keratan sulfate biosynthetic process N-acetylglucosamine metabolic process carbohydrate metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9435


54371

Ensembl


ENSG00000175040


ENSMUSG00000033350

UniProt


Q9Y4C5


Q80WV3

RefSeq (mRNA)


NM_004267


NM_018763

RefSeq (protein)


NP_004258


NP_061233

Location (UCSC)

Chr 3: 143.12 – 143.12 Mb

Chr 9: 95.28 – 95.29 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175040 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033350 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li X, Tedder TF (May 1999). "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization". Genomics. 55 (3): 345–7. doi:10.1006/geno.1998.5653. PMID 10049591.
^ "Entrez Gene: CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2".

External links

Human CHST2 genome location and CHST2 gene details page in the UCSC Genome Browser.

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Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC 237448. PMID 8419650.
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de Graffenried CL, Bertozzi CR (2003). "Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis". J. Biol. Chem. 278 (41): 40282–95. doi:10.1074/jbc.M304928200. PMID 12855678.
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de Graffenried CL, Bertozzi CR (2004). "The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity". J. Biol. Chem. 279 (38): 40035–43. doi:10.1074/jbc.M405709200. PMID 15220337.
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Chen L, Ichihara-Tanaka K, Muramatsu T (2005). "Role of the carboxyl-terminal region in the activity of N-acetylglucosamine 6-o-sulfotransferase-1". J. Biochem. 136 (5): 659–64. doi:10.1093/jb/mvh162. PMID 15632306.
Kanoh A, Seko A, Ideo H, et al. (2007). "Ectopic expression of N-acetylglucosamine 6-O-sulfotransferase 2 in chemotherapy-resistant ovarian adenocarcinomas". Glycoconj. J. 23 (5–6): 453–60. doi:10.1007/s10719-006-6979-6. PMID 16897186. S2CID 22628478.