DNAI2

Protein-coding gene in the species Homo sapiens

DNAI2

Identifiers

Aliases

DNAI2, CILD9, DIC2, dynein axonemal intermediate chain 2

External IDs

OMIM: 605483; MGI: 2685574; HomoloGene: 11311; GeneCards: DNAI2; OMA:DNAI2 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q25.1	Start	74,274,247 bp^[1]
Band	17q25.1	End	74,314,884 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 E2	Start	114,618,234 bp^[2]
Band	11\|11 E2	End	114,648,715 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

bronchial epithelial cell

sperm

trachea

right lung

caput epididymis

left uterine tube

pituitary gland

anterior pituitary

hypothalamus

Top expressed in

spermatid

otolith organ

utricle

seminiferous tubule

olfactory epithelium

spermatocyte

right lung lobe

left lung lobe

trigeminal ganglion

habenula

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	microtubule motor activity cytoskeletal motor activity protein binding plus-end-directed microtubule motor activity dynein light chain binding dynein heavy chain binding
Cellular component	cytoplasm axonemal dynein complex dynein complex axoneme cell projection sperm flagellum cilium microtubule outer dynein arm cytoskeleton external side of plasma membrane
Biological process	cilium movement determination of left/right symmetry outer dynein arm assembly cell projection organization cilium assembly microtubule-based movement
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


64446


432611

Ensembl


ENSG00000171595


ENSMUSG00000034706

UniProt


Q9GZS0


A2AC93

RefSeq (mRNA)


NM_001172810 NM_023036 NM_001353167


NM_001034878

RefSeq (protein)


NP_001166281 NP_075462 NP_001340096


NP_001030050

Location (UCSC)

Chr 17: 74.27 – 74.31 Mb

Chr 11: 114.62 – 114.65 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Dynein axonemal intermediate chain 2 also known as axonemal dynein intermediate chain 2, is a protein that in humans is encoded by the DNAI2 gene.^[5]^[6]

Function

The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella.^[5]

Clinical significance

Mutations in the DNAI2 gene are associated with primary ciliary dyskinesia.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171595 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034706 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: dynein".
^ Pennarun G, Chapelin C, Escudier E, Bridoux AM, Dastot F, Cacheux V, Goossens M, Amselem S, Duriez B (December 2000). "The human dynein intermediate chain 2 gene (DNAI2): cloning, mapping, expression pattern, and evaluation as a candidate for primary ciliary dyskinesia". Hum. Genet. 107 (6): 642–9. doi:10.1007/s004390000427. PMID 11153919. S2CID 21558696.
^ Loges NT, Olbrich H, Fenske L, Mussaffi H, Horvath J, Fliegauf M, Kuhl H, Baktai G, Peterffy E, Chodhari R, Chung EM, Rutman A, O'Callaghan C, Blau H, Tiszlavicz L, Voelkel K, Witt M, Zietkiewicz E, Neesen J, Reinhardt R, Mitchison HM, Omran H (November 2008). "DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm". Am. J. Hum. Genet. 83 (5): 547–58. doi:10.1016/j.ajhg.2008.10.001. PMC 2668028. PMID 18950741.