DNAL4

Protein-coding gene in the species Homo sapiens
DNAL4
Identifiers
AliasesDNAL4, PIG27, MRMV3, dynein axonemal light chain 4
External IDsOMIM: 610565; MGI: 1859217; HomoloGene: 38094; GeneCards: DNAL4; OMA:DNAL4 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for DNAL4
Genomic location for DNAL4
Band22q13.1Start38,778,508 bp[1]
End38,794,198 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for DNAL4
Genomic location for DNAL4
Band15 E1|15 37.85 cMStart79,645,654 bp[2]
End79,662,050 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • anterior pituitary

  • oocyte

  • cingulate gyrus

  • right lobe of thyroid gland

  • amygdala

  • nucleus accumbens

  • left lobe of thyroid gland

  • prefrontal cortex

  • Brodmann area 9
Top expressed in
  • spermatid

  • spermatocyte

  • secondary oocyte

  • entorhinal cortex

  • seminiferous tubule

  • lip

  • superior frontal gyrus

  • neural tube

  • ganglionic eminence

  • proximal tubule
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • cytoskeletal motor activity
  • protein binding
  • microtubule motor activity
  • cytoskeletal protein binding
  • plus-end-directed microtubule motor activity
  • dynein intermediate chain binding
  • dynein light intermediate chain binding
Cellular component
  • cytoplasm
  • plasma membrane
  • cell projection
  • cilium
  • microtubule
  • cytoskeleton
  • dynein complex
Biological process
  • microtubule-based process
  • microtubule-based movement
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10126

54152

Ensembl

ENSG00000100246

ENSMUSG00000022420

UniProt

O96015

Q9DCM4

RefSeq (mRNA)

NM_005740

NM_017470

RefSeq (protein)

NP_005731

NP_059498

Location (UCSC)Chr 22: 38.78 – 38.79 MbChr 15: 79.65 – 79.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dynein light chain 4, axonemal is a protein that in humans is encoded by the DNAL4 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100246 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022420 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  6. ^ "Entrez Gene: DNAL4 dynein, axonemal, light chain 4".

Further reading

  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Iwasaki M, Kuwata T, Yamazaki Y, Jenkins NA, Copeland NG, Osato M, Ito Y, Kroon E, Sauvageau G, Nakamura T (2005). "Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model". Blood. 105 (2): 784–793. doi:10.1182/blood-2004-04-1508. PMID 15454493.
  • Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, Bye JM, Beare DM, Dunham I (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links


  • v
  • t
  • e