GALNT13

Protein-coding gene in the species Homo sapiens
GALNT13
Identifiers
AliasesGALNT13, GalNAc-T13, polypeptide N-acetylgalactosaminyltransferase 13
External IDsOMIM: 608369; MGI: 2139447; HomoloGene: 62167; GeneCards: GALNT13; OMA:GALNT13 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for GALNT13
Genomic location for GALNT13
Band2q23.3-q24.1Start153,871,922 bp[1]
End154,453,979 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for GALNT13
Genomic location for GALNT13
Band2|2 C1.1Start54,436,317 bp[2]
End55,118,309 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar cortex

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • gonad

  • corpus callosum

  • testicle

  • C1 segment

  • Achilles tendon

  • secondary oocyte

  • cerebellar vermis
Top expressed in
  • lobe of cerebellum

  • habenula

  • cerebellar vermis

  • dorsal striatum

  • lumbar spinal ganglion

  • olfactory tubercle

  • lateral septal nucleus

  • nucleus accumbens

  • substantia nigra

  • neural layer of retina
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • glycosyltransferase activity
  • transferase activity
  • metal ion binding
  • carbohydrate binding
  • polypeptide N-acetylgalactosaminyltransferase activity
Cellular component
  • integral component of membrane
  • Golgi membrane
  • Golgi apparatus
  • membrane
Biological process
  • protein glycosylation
  • O-glycan processing
  • protein O-linked glycosylation
  • protein O-linked glycosylation via serine
  • protein O-linked glycosylation via threonine
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

114805

271786

Ensembl

ENSG00000144278

ENSMUSG00000060988

UniProt

Q8IUC8

Q8CF93

RefSeq (mRNA)

NM_001301627
NM_052917

NM_173030

RefSeq (protein)
NP_001288556
NP_443149
NP_001363321
NP_001363323
NP_001363327

NP_001363329
NP_001363330
NP_001363331
NP_001363332
NP_001363333
NP_001363334

NP_766618

Location (UCSC)Chr 2: 153.87 – 154.45 MbChr 2: 54.44 – 55.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polypeptide N-acetylgalactosaminyltransferase 13 is an enzyme that in humans is encoded by the GALNT13 gene.[5][6][7]

The GALNT13 protein is a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAcT; EC 2.4.1.41) family, which initiate O-linked glycosylation of mucins (see MUC3A, MIM 158371) by the initial transfer of N-acetylgalactosamine (GalNAc) with an alpha-linkage to a serine or threonine residue.[supplied by OMIM][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144278 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060988 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Ohara O (Sep 2001). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
  6. ^ Zhang Y, Iwasaki H, Wang H, Kudo T, Kalka TB, Hennet T, Kubota T, Cheng L, Inaba N, Gotoh M, Togayachi A, Guo J, Hisatomi H, Nakajima K, Nishihara S, Nakamura M, Marth JD, Narimatsu H (Dec 2002). "Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen". J Biol Chem. 278 (1): 573–84. doi:10.1074/jbc.M203094200. PMID 12407114.
  7. ^ a b "Entrez Gene: GALNT13 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)".

Further reading

  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.


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