IFT81

IFT81
Identifiers
AliasesIFT81, CDV-1, CDV-1R, CDV1, CDV1R, DV1, intraflagellar transport 81, SRTD19
External IDsOMIM: 605489; MGI: 1098597; HomoloGene: 7664; GeneCards: IFT81; OMA:IFT81 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for IFT81
Genomic location for IFT81
Band12q24.11Start110,124,335 bp[1]
End110,218,793 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for IFT81
Genomic location for IFT81
Band5 F|5 62.44 cMStart122,688,267 bp[2]
End122,752,581 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • ventricular zone

  • right uterine tube

  • ganglionic eminence

  • Achilles tendon

  • olfactory zone of nasal mucosa

  • testicle

  • Epithelium of choroid plexus

  • left testis

  • right testis
Top expressed in
  • spermatid

  • saccule

  • spermatocyte

  • neural layer of retina

  • interventricular septum

  • genital tubercle

  • otic vesicle

  • vestibular sensory epithelium

  • right ventricle

  • olfactory epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • tubulin binding
  • protein binding
Cellular component
  • intraciliary transport particle B
  • ciliary basal body
  • centrosome
  • sperm principal piece
  • cell projection
  • ciliary tip
  • motile cilium
  • sperm midpiece
  • cilium
Biological process
  • cell projection organization
  • spermatogenesis
  • intraciliary transport
  • intraciliary transport involved in cilium assembly
  • cilium assembly
  • regulation of smoothened signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

28981

12589

Ensembl

ENSG00000122970

ENSMUSG00000029469

UniProt

Q8WYA0

O35594

RefSeq (mRNA)
NM_001143779
NM_014055
NM_031473
NM_001347946
NM_001347947

NM_001347948

NM_009879
NM_001358917
NM_001358918
NM_001358919

RefSeq (protein)
NP_001137251
NP_054774
NP_113661
NP_001334875
NP_001334876

NP_001334877
NP_001137251.1
NP_054774.2

NP_034009
NP_001345846
NP_001345847
NP_001345848

Location (UCSC)Chr 12: 110.12 – 110.22 MbChr 5: 122.69 – 122.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Intraflagellar transport protein 81 homolog is a protein that in humans is encoded by the IFT81 gene.[5][6] Together with IFT74/72 it forms a core complex to build IFT particles[7] which are required for cilium formation. Additionally, it interacts with basal body components as CEP170[8] which regulates the disassembly of the cilium.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122970 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029469 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: intraflagellar transport 81 homolog (Chlamydomonas)".
  6. ^ Higashi M, Kobayashi K, Iijima M, Wakana S, Horiuchi M, Yasuda T, Yoshida G, Kanmura Y, Saheki T (December 2000). "Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene". Mamm. Genome. 11 (12): 1053–7. doi:10.1007/s003350010207. PMID 11130971. S2CID 9319574.
  7. ^ Lucker BF, Behal RH, Qin H, Siron LC, Taggart WD, Rosenbaum JL, Cole DG (July 2005). "Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits". J. Biol. Chem. 280 (30): 27688–96. doi:10.1074/jbc.M505062200. PMID 15955805.
  8. ^ Lamla, Stefan (2009). Functional characterisation of the centrosomal protein Cep170 (Thesis). LMU München: Faculty of Biology.

Further reading

  • Melzer D, Perry JR, Hernandez D, et al. (2008). Cheung VG (ed.). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLOS Genet. 4 (5): e1000072. doi:10.1371/journal.pgen.1000072. PMC 2362067. PMID 18464913. Open access icon
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Peng J, Yu L, Horiuchi M, et al. (2002). "Identification of human CDV-1R and mouse Cdv-1R, two novel proteins with putative signal peptides, especially highly expressed in testis and increased with the male sex maturation". Mol. Biol. Rep. 29 (4): 353–62. doi:10.1023/A:1021232518628. PMID 12549821. S2CID 908688.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


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