Ion transporter superfamily

The ion transporter (IT) superfamily is a superfamily of secondary carriers that transport charged substrates.^[1]^[2]

Families

As of early 2016, the currently recognized and functionally defined families that make up the IT superfamily include:

2.A.8 - The Gluconate:H⁺ Symporter (GntP) Family
2.A.11 - The Citrate-Mg²⁺:H⁺ (CitM) Citrate-Ca²⁺:H⁺ (CitH) Symporter (CitMHS) Family
2.A.13 - The C₄-Dicarboxylate Uptake (Dcu) Family
2.A.14 - The Lactate Permease (LctP) Family
2.A.34 - The NhaB Na⁺:H⁺ Antiporter (NhaB) Family
2.A.35 - The NhaC Na⁺:H⁺ Antiporter (NhaC) Family
2.A.45 - The Arsenite-Antimonite (ArsB) Efflux Family
2.A.47 - The Divalent Anion:Na⁺ Symporter (DASS) Family
2.A.61 - The C₄-dicarboxylate Uptake C (DcuC) Family
2.A.62 - The NhaD Na⁺:H⁺ Antiporter (NhaD) Family
2.A.68 - The p-Aminobenzoyl-glutamate Transporter (AbgT) Family
2.A.94 - The Phosphate Permease (Pho1) Family
2.A.101 - The Malonate Uptake (MatC) Family
2.A.111 - The Na⁺/H⁺ Antiporter-E (NhaE) Family
2.A.118 - The Basic Amino Acid Antiporter (ArcD) Family

^ Prakash S, Cooper G, Singhi S, Saier MH (December 2003). "The ion transporter superfamily". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1618 (1): 79–92. doi:10.1016/j.bbamem.2003.10.010. PMID 14643936.
^ Chen JS, Reddy V, Chen JH, Shlykov MA, Zheng WH, Cho J, Yen MR, Saier MH (2011-01-01). "Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments". Journal of Molecular Microbiology and Biotechnology. 21 (3–4): 83–96. doi:10.1159/000334611. PMC 3290041. PMID 22286036.