KIF13A

Protein-coding gene in the species Homo sapiens
KIF13A
Identifiers
AliasesKIF13A, RBKIN, bA500C11.2, kinesin family member 13A
External IDsOMIM: 605433; MGI: 1098264; HomoloGene: 22589; GeneCards: KIF13A; OMA:KIF13A - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for KIF13A
Genomic location for KIF13A
Band6p22.3Start17,759,183 bp[1]
End17,987,635 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for KIF13A
Genomic location for KIF13A
Band13|13 A5Start46,749,087 bp[2]
End46,929,867 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • saphenous vein

  • internal globus pallidus

  • body of tongue

  • right ventricle

  • jejunum

  • synovial joint

  • nipple

  • corpus callosum

  • right coronary artery

  • vena cava
Top expressed in
  • soleus muscle

  • retinal pigment epithelium

  • atrium

  • myocardium of ventricle

  • skeletal muscle tissue

  • temporal muscle

  • digastric muscle

  • triceps brachii muscle

  • ankle

  • sternocleidomastoid muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • microtubule motor activity
  • nucleotide binding
  • microtubule binding
  • ATPase activity
  • protein binding
  • ATP binding
Cellular component
  • cytoplasm
  • endosome
  • centrosome
  • Golgi apparatus
  • trans-Golgi network membrane
  • membrane
  • kinesin complex
  • Golgi membrane
  • microtubule organizing center
  • midbody
  • endosome membrane
  • microtubule
  • cytoskeleton
  • intracellular anatomical structure
Biological process
  • plus-end-directed vesicle transport along microtubule
  • cytoskeleton-dependent intracellular transport
  • endosome to lysosome transport
  • cell division
  • melanosome organization
  • microtubule-based movement
  • vesicle cargo loading
  • protein transport
  • cell cycle
  • intracellular protein transport
  • Golgi to plasma membrane protein transport
  • regulation of cytokinesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

63971

16553

Ensembl

ENSG00000137177

ENSMUSG00000021375

UniProt

Q9H1H9

Q9EQW7

RefSeq (mRNA)

NM_001105566
NM_001105567
NM_001105568
NM_001243423
NM_022113

NM_010617

RefSeq (protein)

NP_001099036
NP_001099037
NP_001099038
NP_001230352
NP_071396

NP_034747

Location (UCSC)Chr 6: 17.76 – 17.99 MbChr 13: 46.75 – 46.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin-like protein KIF13A is a protein that in humans is encoded by the KIF13A gene.[5][6]


Interactions

KIF13A has been shown to interact with AP1B1.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137177 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021375 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K, Hirokawa N (Jan 2001). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell. 103 (4): 569–81. doi:10.1016/S0092-8674(00)00161-6. PMID 11106728. S2CID 18245989.
  6. ^ "Entrez Gene: KIF13A kinesin family member 13A".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • De Graeve F, Bahr A, Chatton B, Kedinger C (2000). "A murine ATFa-associated factor with transcriptional repressing activity". Oncogene. 19 (14): 1807–19. doi:10.1038/sj.onc.1203492. PMID 10777215.
  • Jamain S, Quach H, Fellous M, Bourgeron T (2001). "Identification of the human KIF13A gene homologous to Drosophila kinesin-73 and candidate for schizophrenia". Genomics. 74 (1): 36–44. doi:10.1006/geno.2001.6535. PMID 11374900.
  • Chen D, Pajovic S, Duckett A, et al. (2002). "Genomic amplification in retinoblastoma narrowed to 0.6 megabase on chromosome 6p containing a kinesin-like gene, RBKIN". Cancer Res. 62 (4): 967–71. PMID 11861365.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.


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