KIFC3

Protein-coding gene in the species Homo sapiens
KIFC3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2H58

Identifiers
AliasesKIFC3, kinesin family member C3
External IDsOMIM: 604535; MGI: 109202; HomoloGene: 124421; GeneCards: KIFC3; OMA:KIFC3 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for KIFC3
Genomic location for KIFC3
Band16q21Start57,758,217 bp[1]
End57,863,053 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for KIFC3
Genomic location for KIFC3
Band8 C5|8 47.12 cMStart95,826,456 bp[2]
End95,929,440 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • sural nerve

  • body of pancreas

  • right lobe of liver

  • upper lobe of left lung

  • skin of abdomen

  • right lung

  • renal medulla

  • left ventricle
Top expressed in
  • right ventricle

  • lip

  • spermatocyte

  • spermatid

  • molar

  • islet of Langerhans

  • morula

  • myocardium of ventricle

  • adrenal gland

  • yolk sac
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • microtubule motor activity
  • nucleotide binding
  • microtubule binding
  • minus-end-directed microtubule motor activity
  • ATPase activity
  • protein binding
  • ATP binding
Cellular component
  • cytoplasm
  • centrosome
  • Golgi apparatus
  • membrane
  • adherens junction
  • microtubule organizing center
  • cell junction
  • zonula adherens
  • microtubule
  • extracellular exosome
  • cytoplasmic vesicle membrane
  • cytoskeleton
  • cytoplasmic vesicle
  • kinesin complex
Biological process
  • Golgi organization
  • epithelial cell-cell adhesion
  • microtubule-based movement
  • zonula adherens maintenance
  • microtubule-based process
  • visual perception
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3801

16582

Ensembl

ENSG00000140859

ENSMUSG00000031788

UniProt

Q9BVG8

O35231

RefSeq (mRNA)
NM_001130099
NM_001130100
NM_005550
NM_001318710
NM_001318711

NM_001318712
NM_001318713
NM_001318714
NM_001318715

NM_001145831
NM_001145832
NM_010631
NM_001372312
NM_001372313

NM_001372314
NM_001372315
NM_001372316
NM_001372317

RefSeq (protein)
NP_001123571
NP_001123572
NP_001305639
NP_001305640
NP_001305641

NP_001305642
NP_001305643
NP_001305644
NP_005541

NP_001139303
NP_001139304
NP_034761
NP_001359241
NP_001359242

NP_001359243
NP_001359244
NP_001359245
NP_001359246

Location (UCSC)Chr 16: 57.76 – 57.86 MbChr 8: 95.83 – 95.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin-like protein KIFC3 is a protein that in humans is encoded by the KIFC3 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140859 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031788 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hoang EH, Whitehead JL, Dose AC, Burnside B (Dec 1998). "Cloning of a novel C-terminal kinesin (KIFC3) that maps to human chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl syndrome". Genomics. 52 (2): 219–22. doi:10.1006/geno.1998.5431. PMID 9782090.
  6. ^ "Entrez Gene: KIFC3 kinesin family member C3".

Further reading

  • Diu A, Moebius U, Ferradini L, et al. (1993). "Limited T-cell receptor diversity in liver-infiltrating lymphocytes from patients with primary biliary cirrhosis". J. Autoimmun. 6 (5): 611–9. doi:10.1006/jaut.1993.1050. PMID 8240664.
  • Hoang E, Bost-Usinger L, Burnside B (1999). "Characterization of a novel C-kinesin (KIFC3) abundantly expressed in vertebrate retina and RPE". Exp. Eye Res. 69 (1): 57–68. doi:10.1006/exer.1999.0671. PMID 10375449.
  • Noda Y, Okada Y, Saito N, et al. (2001). "KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes". J. Cell Biol. 155 (1): 77–88. doi:10.1083/jcb.200108042. PMC 2150803. PMID 11581287.
  • Xu Y, Takeda S, Nakata T, et al. (2002). "Role of KIFC3 motor protein in Golgi positioning and integration". J. Cell Biol. 158 (2): 293–303. doi:10.1083/jcb.200202058. PMC 2173137. PMID 12135985.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Roni V, Carpio R, Wissinger B (2007). "Mapping of transcription start sites of human retina expressed genes". BMC Genomics. 8: 42. doi:10.1186/1471-2164-8-42. PMC 1802077. PMID 17286855.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9BVG8 (Human Kinesin-like protein KIFC3) at the PDBe-KB.
  • v
  • t
  • e
  • 2h58: Crystal structure of the KIFC3 motor domain in complex with ADP
    2h58: Crystal structure of the KIFC3 motor domain in complex with ADP


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