LSM4

Protein-coding gene in the species Homo sapiens
LSM4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3JCR

Identifiers
AliasesLSM4, GRP, YER112W, LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDsOMIM: 607284; MGI: 1354692; HomoloGene: 134555; GeneCards: LSM4; OMA:LSM4 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for LSM4
Genomic location for LSM4
Band19p13.11Start18,306,236 bp[1]
End18,323,112 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for LSM4
Genomic location for LSM4
Band8|8 B3.3Start71,125,898 bp[2]
End71,131,402 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • right testis

  • left testis

  • ventricular zone

  • right adrenal gland

  • right adrenal cortex

  • left adrenal cortex

  • embryo

  • ganglionic eminence

  • apex of heart
Top expressed in
  • yolk sac

  • thymus

  • bone marrow

  • lens

  • epiblast

  • ventricular zone

  • proximal tubule

  • embryo

  • ileum

  • ganglionic eminence
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • U6 snRNA binding
  • RNA binding
  • PH domain binding
Cellular component
  • spliceosomal tri-snRNP complex
  • U6 snRNP
  • P-body
  • nucleoplasm
  • neuron projection
  • spliceosomal complex
  • nucleus
  • cytosol
  • membrane
  • protein-containing complex
  • U4/U6 x U5 tri-snRNP complex
  • U2-type precatalytic spliceosome
  • Lsm2-8 complex
Biological process
  • RNA processing
  • mRNA processing
  • spliceosomal snRNP assembly
  • spliceosomal complex assembly
  • P-body assembly
  • exonucleolytic catabolism of deadenylated mRNA
  • RNA splicing
  • mRNA splicing, via spliceosome
  • nuclear-transcribed mRNA catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25804

50783

Ensembl

ENSG00000130520

ENSMUSG00000031848

UniProt

Q9Y4Z0

Q9QXA5

RefSeq (mRNA)

NM_012321
NM_001252129

NM_015816
NM_001359042

RefSeq (protein)

NP_001239058
NP_036453

NP_056631
NP_001345971

Location (UCSC)Chr 19: 18.31 – 18.32 MbChr 8: 71.13 – 71.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.[5][6][7]

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130520 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031848 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
  6. ^ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
  7. ^ a b "Entrez Gene: LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

Further reading

  • Singer J, Roberts-Ems J, Luthardt FW, Riggs AD (1980). "Methylation of DNA in mouse early embryos, teratocarcinoma cells and adult tissues of mouse and rabbit". Nucleic Acids Res. 7 (8): 2369–85. doi:10.1093/nar/7.8.2369. PMC 342390. PMID 523320.
  • Friesen WJ, Dreyfuss G (2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)". J. Biol. Chem. 275 (34): 26370–5. doi:10.1074/jbc.M003299200. PMID 10851237.
  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  • Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum. 46 (3): 726–34. doi:10.1002/art.10220. PMID 11920408.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726. PMC 1370355. PMID 12515382.
  • Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Fürst J, Schedlbauer A, Gandini R, et al. (2005). "ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4". J. Biol. Chem. 280 (35): 31276–82. doi:10.1074/jbc.M500541200. PMID 15905169.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Yang ZQ, Streicher KL, Ray ME, et al. (2007). "Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer". Cancer Res. 66 (24): 11632–43. doi:10.1158/0008-5472.CAN-06-2946. PMID 17178857.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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