MAPK4

Protein-coding gene in the species Homo sapiens
MAPK4
Identifiers
AliasesMAPK4, ERK-4, ERK4, PRKM4, p63-MAPK, p63MAPK, mitogen-activated protein kinase 4
External IDsOMIM: 176949; MGI: 2444559; HomoloGene: 2058; GeneCards: MAPK4; OMA:MAPK4 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for MAPK4
Genomic location for MAPK4
Band18q21.1-q21.2Start50,560,087 bp[1]
End50,731,826 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for MAPK4
Genomic location for MAPK4
Band18|18 E2Start73,928,486 bp[2]
End74,065,359 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • caudate nucleus

  • nucleus accumbens

  • right frontal lobe

  • anterior cingulate cortex

  • putamen

  • right adrenal cortex

  • right hemisphere of cerebellum

  • left adrenal cortex

  • amygdala

  • prefrontal cortex
Top expressed in
  • olfactory tubercle

  • habenula

  • visual cortex

  • Epithelium of choroid plexus

  • superior frontal gyrus

  • primary visual cortex

  • primary motor cortex

  • prefrontal cortex

  • globus pallidus

  • cingulate gyrus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein serine/threonine kinase activity
  • ATP binding
  • kinase activity
  • protein heterodimerization activity
  • nucleotide binding
  • protein kinase binding
  • protein homodimerization activity
  • protein kinase activity
  • transferase activity
  • protein binding
  • MAP kinase activity
Cellular component
  • cytosol
  • nucleoplasm
  • nucleus
  • cytoplasm
Biological process
  • protein phosphorylation
  • cell cycle
  • phosphorylation
  • MAPK cascade
  • regulation of gene expression
  • cellular response to organic substance
  • intracellular signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5596

225724

Ensembl

ENSG00000141639
ENSG00000282110

ENSMUSG00000024558

UniProt

P31152

Q6P5G0

RefSeq (mRNA)

NM_001292039
NM_001292040
NM_002747

NM_172632
NM_001360936

RefSeq (protein)

NP_001278968
NP_001278969
NP_002738

NP_766220
NP_001347865

Location (UCSC)Chr 18: 50.56 – 50.73 MbChr 18: 73.93 – 74.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.[5][6]

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.[6]

The Arabidopsis MAPK4 is important in signalling [7]

Mechanistically, MAPK4 directly bound and activated AKT by phosphorylation of the activation loop at threonine 308. It also activated mTORC2 to phosphorylate AKT at serine 473 for full activation. MAPK4 overexpression induced oncogenic outcomes, including transforming prostate epithelial cells into anchorage-independent growth, and MAPK4 knockdown inhibited cancer cell proliferation, anchorage-independent growth, and xenograft growth.[8]

References

  1. ^ a b c ENSG00000282110 GRCh38: Ensembl release 89: ENSG00000141639, ENSG00000282110 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024558 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Li L, Wysk M, Gonzalez FA, Davis RJ (February 1994). "Genomic loci of human mitogen-activated protein kinases". Oncogene. 9 (2): 647–9. PMID 8290275.
  6. ^ a b "Entrez Gene: MAPK4 mitogen-activated protein kinase 4".
  7. ^ Petersen M, Brodersen P, Naested H, Andreasson E, Lindhart U, Johansen B, et al. (December 2000). "Arabidopsis map kinase 4 negatively regulates systemic acquired resistance". Cell. 103 (7): 1111–20. doi:10.1016/S0092-8674(00)00213-0. PMID 11163186. S2CID 1864451.
  8. ^ Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, et al. (March 2019). "MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling". The Journal of Clinical Investigation. 129 (3): 1015–1029. doi:10.1172/JCI97712. PMC 6391107. PMID 30688659.

Further reading

  • Seger R, Krebs EG (June 1995). "The MAPK signaling cascade". FASEB Journal. 9 (9): 726–35. doi:10.1096/fasebj.9.9.7601337. PMID 7601337. S2CID 23298305.
  • Davis RJ (December 1995). "Transcriptional regulation by MAP kinases". Molecular Reproduction and Development. 42 (4): 459–67. doi:10.1002/mrd.1080420414. PMID 8607977. S2CID 12842112.
  • Robinson MJ, Cobb MH (April 1997). "Mitogen-activated protein kinase pathways". Current Opinion in Cell Biology. 9 (2): 180–6. doi:10.1016/S0955-0674(97)80061-0. PMID 9069255.
  • Gonzalez FA, Raden DL, Rigby MR, Davis RJ (June 1992). "Heterogeneous expression of four MAP kinase isoforms in human tissues". FEBS Letters. 304 (2–3): 170–8. doi:10.1016/0014-5793(92)80612-K. PMID 1319925. S2CID 42548392.
  • Zhu AX, Zhao Y, Moller DE, Flier JS (December 1994). "Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3". Molecular and Cellular Biology. 14 (12): 8202–11. doi:10.1128/mcb.14.12.8202. PMC 359359. PMID 7969157.
  • Kinet S, Bernard F, Mongellaz C, Perreau M, Goldman FD, Taylor N (October 2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes". Blood. 100 (7): 2546–53. doi:10.1182/blood-2002-03-0819. PMID 12239168.
  • Sun M, Wei Y, Yao L, Xie J, Chen X, Wang H, et al. (February 2006). "Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3". Biochemical and Biophysical Research Communications. 340 (1): 209–14. doi:10.1016/j.bbrc.2005.12.003. PMID 16360641.
  • Kant S, Schumacher S, Singh MK, Kispert A, Kotlyarov A, Gaestel M (November 2006). "Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5". The Journal of Biological Chemistry. 281 (46): 35511–9. doi:10.1074/jbc.M606693200. PMID 16973613.

External links

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Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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