MAPRE3

Protein-coding gene in the species Homo sapiens
MAPRE3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WYO, 3CO1, 3JAK, 3JAL, 3JAR, 3TQ7

Identifiers
AliasesMAPRE3, EB3, EBF3, EBF3-S, RP3, microtubule associated protein RP/EB family member 3
External IDsOMIM: 605788; MGI: 2140967; HomoloGene: 56565; GeneCards: MAPRE3; OMA:MAPRE3 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for MAPRE3
Genomic location for MAPRE3
Band2p23.3Start26,970,637 bp[1]
End27,027,219 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for MAPRE3
Genomic location for MAPRE3
Band5|5 B1Start30,971,985 bp[2]
End31,023,450 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 10

  • right uterine tube

  • middle frontal gyrus

  • frontal pole

  • cingulate gyrus

  • anterior pituitary

  • cerebellar vermis

  • nucleus accumbens

  • Brodmann area 9

  • amygdala
Top expressed in
  • superior frontal gyrus

  • cerebellar cortex

  • spermatid

  • entorhinal cortex

  • lip

  • dorsomedial hypothalamic nucleus

  • habenula

  • superior colliculus

  • primary motor cortex

  • subiculum
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • microtubule binding
  • protein binding
  • identical protein binding
  • protein C-terminus binding
  • protein kinase binding
  • microtubule plus-end binding
Cellular component
  • microtubule cytoskeleton
  • microtubule plus-end
  • perinuclear region of cytoplasm
  • cytoplasmic microtubule
  • midbody
  • microtubule
  • cytoskeleton
  • cytoplasm
  • microtubule organizing center
  • spindle midzone
  • mitotic spindle astral microtubule end
Biological process
  • positive regulation of transcription, DNA-templated
  • cell cycle
  • positive regulation of microtubule plus-end binding
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity
  • cell division
  • protein localization
  • regulation of microtubule polymerization or depolymerization
  • protein localization to microtubule
  • positive regulation of protein kinase activity
  • spindle assembly
  • protein localization to microtubule plus-end
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22924

100732

Ensembl

ENSG00000084764

ENSMUSG00000029166

UniProt

Q9UPY8

Q6PER3

RefSeq (mRNA)

NM_001303050
NM_012326

NM_133350
NM_001310516

RefSeq (protein)

NP_001289979
NP_036458

NP_001297445
NP_579928

Location (UCSC)Chr 2: 26.97 – 27.03 MbChr 5: 30.97 – 31.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Microtubule-associated protein RP/EB family member 3 is a protein that in humans is encoded by the MAPRE3 gene.[5][6]

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000084764 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029166 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol. 159 (3): 1276–83. doi:10.4049/jimmunol.159.3.1276. PMID 9233623. S2CID 23797920.
  6. ^ a b "Entrez Gene: MAPRE3 microtubule-associated protein, RP/EB family, member 3".

Further reading

  • Juwana JP, Henderikx P, Mischo A, et al. (1999). "EB/RP gene family encodes tubulin binding proteins". Int. J. Cancer. 81 (2): 275–84. doi:10.1002/(SICI)1097-0215(19990412)81:2<275::AID-IJC18>3.0.CO;2-Z. PMID 10188731. S2CID 33232892.
  • Nakagawa H, Koyama K, Murata Y, et al. (2000). "EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue". Oncogene. 19 (2): 210–6. doi:10.1038/sj.onc.1203308. PMID 10644998. S2CID 2284265.
  • Su LK, Qi Y (2001). "Characterization of human MAPRE genes and their proteins". Genomics. 71 (2): 142–9. doi:10.1006/geno.2000.6428. PMID 11161807.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bu W, Su LK (2004). "Characterization of functional domains of human EB1 family proteins". J. Biol. Chem. 278 (50): 49721–31. doi:10.1074/jbc.M306194200. PMID 14514668.
  • Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC 2171674. PMID 15631994.
  • Yeh TY, Chuang JZ, Sung CH (2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway". J. Cell Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • v
  • t
  • e
  • 1wyo: Solution structure of the CH domain of human microtubule-associated protein RP/EB family member 3
    1wyo: Solution structure of the CH domain of human microtubule-associated protein RP/EB family member 3


Stub icon

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e