METTL14

Protein-coding gene in the species Homo sapiens
METTL14
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5IL1, 5K7W, 5IL2, 5IL0, 5K7M, 5K7U

Identifiers
AliasesMETTL14, methyltransferase like 14, hmethyltransferase 14, N6-adenosine-methyltransferase subunit
External IDsOMIM: 616504; MGI: 2442926; HomoloGene: 10865; GeneCards: METTL14; OMA:METTL14 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for METTL14
Genomic location for METTL14
Band4q26Start118,685,392 bp[1]
End118,715,433 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for METTL14
Genomic location for METTL14
Band3|3 G1Start123,161,946 bp[2]
End123,179,757 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • secondary oocyte

  • tail of epididymis

  • islet of Langerhans

  • caput epididymis

  • corpus epididymis

  • ventricular zone

  • epithelium of colon

  • thymus

  • pancreatic epithelial cell
Top expressed in
  • hand

  • ascending aorta

  • aortic valve

  • otolith organ

  • utricle

  • primitive streak

  • tail of embryo

  • efferent ductule

  • epiblast

  • supraoptic nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • RNA binding
  • mRNA binding
  • S-adenosyl-L-methionine binding
  • protein binding
  • mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
Cellular component
  • RNA N6-methyladenosine methyltransferase complex
  • nucleus
  • nucleoplasm
Biological process
  • stem cell population maintenance
  • mRNA splicing, via spliceosome
  • mRNA destabilization
  • mRNA methylation
  • RNA methylation
  • mRNA catabolic process
  • spermatogenesis
  • forebrain radial glial cell differentiation
  • gliogenesis
  • cell differentiation
  • RNA metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57721

210529

Ensembl

ENSG00000145388

ENSMUSG00000028114

UniProt

Q9HCE5

Q3UIK4

RefSeq (mRNA)

NM_020961

NM_201638

RefSeq (protein)

NP_066012

NP_964000

Location (UCSC)Chr 4: 118.69 – 118.72 MbChr 3: 123.16 – 123.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Methyltransferase like 14 is a protein that in humans is encoded by the METTL14 gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145388 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028114 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Methyltransferase like 14". Retrieved 2018-03-20.

Further reading

  • Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (June 2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Hum. Mol. Genet. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
  • Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C (February 2014). "A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation". Nat. Chem. Biol. 10 (2): 93–5. doi:10.1038/nchembio.1432. PMC 3911877. PMID 24316715.
  • Wang X, Feng J, Xue Y, Guan Z, Zhang D, Liu Z, Gong Z, Wang Q, Huang J, Tang C, Zou T, Yin P (June 2016). "Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex". Nature. 534 (7608): 575–8. Bibcode:2016Natur.534..575W. doi:10.1038/nature18298. PMID 27281194. S2CID 4448430.
  • Śledź P, Jinek M (September 2016). "Structural insights into the molecular mechanism of the m(6)A writer complex". eLife. 5. doi:10.7554/eLife.18434. PMC 5023411. PMID 27627798.


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