MTIF2

Protein-coding gene in the species Homo sapiens
MTIF2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CRV

Identifiers
AliasesMTIF2, mitochondrial translational initiation factor 2
External IDsOMIM: 603766; MGI: 1924034; HomoloGene: 1840; GeneCards: MTIF2; OMA:MTIF2 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for MTIF2
Genomic location for MTIF2
Band2p16.1Start55,236,595 bp[1]
End55,269,347 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for MTIF2
Genomic location for MTIF2
Band11|11 A3.3Start29,476,408 bp[2]
End29,495,279 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • biceps brachii

  • parietal pleura

  • visceral pleura

  • germinal epithelium

  • epithelium of colon

  • Skeletal muscle tissue of biceps brachii

  • tibia

  • right ventricle

  • rectum

  • jejunum
Top expressed in
  • tail of embryo

  • myocardium of ventricle

  • genital tubercle

  • plantaris muscle

  • cardiac muscle tissue of left ventricle

  • brown adipose tissue

  • digastric muscle

  • medial ganglionic eminence

  • soleus muscle

  • right ventricle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • translation factor activity, RNA binding
  • translation initiation factor activity
  • ribosomal small subunit binding
  • RNA binding
  • GTPase activity
Cellular component
  • intracellular anatomical structure
  • mitochondrion
  • nucleoplasm
Biological process
  • translational initiation
  • ribosome disassembly
  • protein biosynthesis
  • regulation of translational initiation
  • mitochondrial translational initiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4528

76784

Ensembl

ENSG00000085760

ENSMUSG00000020459

UniProt

P46199
Q6P1N2

Q91YJ5

RefSeq (mRNA)
NM_001005369
NM_002453
NM_001321001
NM_001321002
NM_001321003

NM_001321004
NM_001321005

NM_001282118
NM_001282119
NM_001282120
NM_133767

RefSeq (protein)
NP_001005369
NP_001307930
NP_001307931
NP_001307932
NP_001307933

NP_001307934
NP_002444
NP_001005369.1
NP_002444.2

NP_001269047
NP_001269048
NP_001269049
NP_598528

Location (UCSC)Chr 2: 55.24 – 55.27 MbChr 11: 29.48 – 29.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.[5][6][7]

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000085760 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020459 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bonner DS, Wiley JE, Farwell MA (Mar 1999). "Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16→p14 by in situ hybridization and with somatic cell hybrids". Cytogenet Cell Genet. 83 (1–2): 80–1. doi:10.1159/000015133. PMID 9925935. S2CID 23290955.
  6. ^ Ma L, Spremulli LL (Feb 1995). "Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA". J Biol Chem. 270 (4): 1859–65. doi:10.1074/jbc.270.4.1859. PMID 7829522.
  7. ^ a b "Entrez Gene: MTIF2 mitochondrial translational initiation factor 2".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Overman RG, Enderle PJ, Farrow JM, et al. (2003). "The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene". Biochim. Biophys. Acta. 1628 (3): 195–205. doi:10.1016/s0167-4781(03)00144-1. PMID 12932832.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Miura E, Kato Y, Matsushima R, et al. (2007). "The Balance between Protein Synthesis and Degradation in Chloroplasts Determines Leaf Variegation in Arabidopsis yellow variegated Mutants". Plant Cell. 19 (4): 1313–28. doi:10.1105/tpc.106.049270. PMC 1913758. PMID 17416734.


  • v
  • t
  • e