MTMR3

MTMR3
Identifiers
Aliases	MTMR3, FYVE-DSP1, ZFYVE10, myotubularin related protein 3
External IDs	OMIM: 603558; MGI: 1921552; HomoloGene: 23662; GeneCards: MTMR3; OMA:MTMR3 - orthologs
EC number	3.1.3.95
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 29,883,169 bp[1] End 30,030,868 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 4,430,868 bp[2] End 4,544,863 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte blood bone marrow cells right uterine tube skin of leg monocyte sural nerve Achilles tendon amniotic fluid Top expressed in blood vestibular membrane of cochlear duct granulocyte transitional epithelium of urinary bladder ciliary body facial motor nucleus ankle iris substantia nigra epithelium of lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity metal ion binding protein tyrosine phosphatase activity hydrolase activity protein binding protein serine/threonine phosphatase activity phosphatidylinositol-3-phosphatase activity phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity protein phosphatase binding Cellular component cytoplasm cytosol membrane extrinsic component of membrane nucleoplasm Biological process cellular response to glucose starvation lipid metabolism protein dephosphorylation regulation of autophagosome assembly phosphatidylinositol dephosphorylation phosphatidylinositol biosynthetic process macroautophagy dephosphorylation peptidyl-tyrosine dephosphorylation phosphatidylinositol 5-phosphate metabolic process regulation of phosphatidylinositol dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8897 74302 Ensembl ENSG00000100330 ENSMUSG00000034354 UniProt Q13615 Q8K296 RefSeq (mRNA) NM_001013676 NM_021090 NM_153050 NM_153051 NM_028860 NM_001373897 RefSeq (protein) NP_066576 NP_694690 NP_694691 NP_694691.1 NP_083136 NP_001360826 Location (UCSC) Chr 22: 29.88 – 30.03 Mb Chr 11: 4.43 – 4.54 Mb PubMed search [3] [4]
Wikidata
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Myotubularin-related protein 3 is a protein that in humans is encoded by the MTMR3 gene.^[5][6][7]

This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.^[7]

References

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