PABPC3

Protein-coding gene in the species Homo sapiens
PABPC3
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

4IVE

Identifiers
AliasesPABPC3, PABP3, PABPL3, tPABP, poly(A) binding protein cytoplasmic 3
External IDsOMIM: 604680 HomoloGene: 118007 GeneCards: PABPC3
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for PABPC3
Genomic location for PABPC3
Band13q12.13Start25,096,136 bp[1]
End25,099,254 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parotid gland

  • amniotic fluid

  • pancreatic ductal cell

  • seminal vesicula

  • pylorus

  • lactiferous duct

  • oral cavity

  • vulva

  • tibia

  • nipple
    n/a
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • poly(A) binding
  • RNA binding
  • nucleic acid binding
  • mRNA 3'-UTR binding
  • poly(U) RNA binding
Cellular component
  • cytoplasm
  • extracellular exosome
  • cytosol
  • nucleus
  • cytoplasmic stress granule
  • ribonucleoprotein complex
Biological process
  • mRNA metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5042

n/a

Ensembl

ENSG00000151846

n/a

UniProt

Q9H361

n/a

RefSeq (mRNA)

NM_030979

n/a

RefSeq (protein)

NP_112241

n/a

Location (UCSC)Chr 13: 25.1 – 25.1 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Polyadenylate-binding protein 3 is a protein that in humans is encoded by the PABPC3 gene.[3][4][5] PABPC3 is a member of a larger family of poly(A)-binding proteins in the human genome.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151846 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Morris CM, Bodger MP (Mar 1993). "Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization". Genomics. 15 (1): 209–11. doi:10.1006/geno.1993.1037. PMID 8432538.
  4. ^ Feral C, Mattei MG, Pawlak A, Guellaen G (Nov 1999). "Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes". Hum Genet. 105 (4): 347–53. doi:10.1007/s004399900148. PMC 1865476. PMID 10543404.
  5. ^ "Entrez Gene: PABPC3 poly(A) binding protein, cytoplasmic 3".

Further reading

  • Marques AC, Dupanloup I, Vinckenbosch N, et al. (2006). "Emergence of young human genes after a burst of retroposition in primates". PLOS Biol. 3 (11): e357. doi:10.1371/journal.pbio.0030357. PMC 1251493. PMID 16201836.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Féral C, Guellaën G, Pawlak A (2002). "Human testis expresses a specific poly(A)-binding protein". Nucleic Acids Res. 29 (9): 1872–83. doi:10.1093/nar/29.9.1872. PMC 37253. PMID 11328870.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Hoshino S, Imai M, Kobayashi T, et al. (1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein". J. Biol. Chem. 274 (24): 16677–80. doi:10.1074/jbc.274.24.16677. PMID 10358005.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Polyadenylate-binding protein 3 (PABPC3)
  • v
  • t
  • e
  • 1g9l: SOLUTION STRUCTURE OF THE PABC DOMAIN OF HUMAN POLY(A) BINDING PROTEIN
    1g9l: SOLUTION STRUCTURE OF THE PABC DOMAIN OF HUMAN POLY(A) BINDING PROTEIN
  • 1jgn: Solution structure of the C-terminal PABC domain of human poly(A)-binding protein in complex with the peptide from Paip2
    1jgn: Solution structure of the C-terminal PABC domain of human poly(A)-binding protein in complex with the peptide from Paip2
  • 1jh4: Solution structure of the C-terminal PABC domain of human poly(A)-binding protein in complex with the peptide from Paip1
    1jh4: Solution structure of the C-terminal PABC domain of human poly(A)-binding protein in complex with the peptide from Paip1
  • 2d9p: Solution structure of RNA binding domain 4 in Polyadenylation binding protein 3
    2d9p: Solution structure of RNA binding domain 4 in Polyadenylation binding protein 3


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