PNRC2

Protein-coding gene in the species Homo sapiens
PNRC2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4B6H

Identifiers
AliasesPNRC2, proline rich nuclear receptor coactivator 2
External IDsOMIM: 611882; MGI: 106512; HomoloGene: 9821; GeneCards: PNRC2; OMA:PNRC2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PNRC2
Genomic location for PNRC2
Band1p36.11Start23,956,839 bp[1]
End23,963,462 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for PNRC2
Genomic location for PNRC2
Band4 D3|4 68.01 cMStart135,598,229 bp[2]
End135,601,161 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • germinal epithelium

  • mucosa of sigmoid colon

  • parietal pleura

  • trabecular bone

  • tail of epididymis

  • visceral pleura

  • lactiferous duct

  • lower lobe of lung

  • epithelium of nasopharynx

  • mucosa of urinary bladder
Top expressed in
  • parotid gland

  • external carotid artery

  • seminal vesicula

  • medial ganglionic eminence

  • internal carotid artery

  • pituitary gland

  • molar

  • atrium

  • Paneth cell

  • cumulus cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • P-body
  • nucleus
  • cytoplasm
  • nucleoplasm
  • Golgi apparatus
  • cytosol
Biological process
  • regulation of transcription, DNA-templated
  • deadenylation-independent decapping of nuclear-transcribed mRNA
  • transcription, DNA-templated
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55629

52830

Ensembl

ENSG00000189266

ENSMUSG00000028675

UniProt

Q9NPJ4

Q9CR73

RefSeq (mRNA)

NM_017761

NM_026383

RefSeq (protein)

NP_060231

NP_080659

Location (UCSC)Chr 1: 23.96 – 23.96 MbChr 4: 135.6 – 135.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proline-rich nuclear receptor coactivator 2 is a protein that in humans is encoded by the PNRC2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000189266 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028675 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhou D, Chen S (Sep 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. doi:10.1093/nar/29.19.3939. PMC 60244. PMID 11574675.
  6. ^ "Entrez Gene: PNRC2 proline-rich nuclear receptor coactivator 2".

Further reading

  • Zhou D, Quach KM, Yang C, et al. (2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. doi:10.1210/mend.14.7.0480. PMID 10894149.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hentschke M, Borgmeyer U (2004). "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma". Biochem. Biophys. Res. Commun. 312 (4): 975–82. doi:10.1016/j.bbrc.2003.11.025. PMID 14651967.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

External links

  • PNRC2 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • NURSA C185
  • Overview of all the structural information available in the PDB for UniProt: Q9NPJ4 (Human Proline-rich nuclear receptor coactivator 2) at the PDBe-KB.


  • v
  • t
  • e
Coactivators
Corepressors
ATP-dependent remodeling factors
  • Chromatin Structure Remodeling (RSC) Complex
  • SWI/SNF


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