Post-translational regulation

Control of the levels of active protein

Post-translational regulation refers to the control of the levels of active protein.

There are several forms.^[1]

It is performed either by means of reversible events (posttranslational modifications, such as phosphorylation or sequestration) or by means of irreversible events (proteolysis).

References

^ Wolfgang Schumann; Wolfgang Schumann (Prof. Dr. rer. nat.) (2006). Dynamics of the bacterial chromosome: structure and function. Wiley-VCH. pp. 266–. ISBN 978-3-527-30496-7. Retrieved 26 December 2010.

Gene expression

Introduction
to genetics

Genetic code
Central dogma
- DNA → RNA → Protein
Special transfers
- RNA→RNA
- RNA→DNA
- Protein→Protein

Transcription

Types	Bacterial Archaeal Eukaryotic
Key elements	Transcription factor RNA polymerase Promoter
Post-transcription	Precursor mRNA (pre-mRNA / hnRNA) 5' capping Splicing Polyadenylation Histone acetylation and deacetylation

Translation

Types	Bacterial Archaeal Eukaryotic
Key elements	Ribosome Transfer RNA (tRNA) Ribosome-nascent chain complex (RNC) Post-translational modification

Regulation

Epigenetic
- imprinting
Transcriptional
- Gene regulatory network
- cis-regulatory element
lac operon
Post-transcriptional
Translational
Post-translational
- reversible
- irreversible

Influential people

Molecular biology

Overview

Central dogma	DNA replication (DNA) Transcription (RNA) Translation (protein)
Element	Genetic Heredity Promoter Pribnow box TATA box Operon gal operon lac operon trp operon Intron Exon Terminator Enhancer Repressor lac repressor trp repressor Silencer Histone methylation
Linked life	Cell biology Biochemistry Computational biology Developmental biology Functional biology/medicine Genetics

Engineering

Concepts	Cultured meat Mitosis Cell signalling Post-transcriptional modification Post-translational modification Dry lab / Wet lab
Techniques	Cell culture Model organisms (such as C57BL/6 mice) Methods Nucleic acid Protein Fluorescence, Pigment & Radioactivity High-throughput technique ("-omics") DNA microarray Mass spectrometry Lab-on-a-chip
Gene regulation	Epigenetic Genetic Post-transcriptional Post-translational regulation