RGS12

Protein-coding gene in the species Homo sapiens

RGS12

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2EBZ, 2KV8

Identifiers

Aliases

RGS12, regulator of G protein signaling 12

External IDs

OMIM: 602512; MGI: 1918979; HomoloGene: 2195; GeneCards: RGS12; OMA:RGS12 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4p16.3	Start	3,293,021 bp^[1]
Band	4p16.3	End	3,439,913 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 B2\|5 17.96 cM	Start	35,106,789 bp^[2]
Band	5 B2\|5 17.96 cM	End	35,196,988 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

ventricular zone

mucosa of esophagus

skin of leg

right uterine tube

skin of abdomen

right frontal lobe

right hemisphere of cerebellum

prefrontal cortex

ectocervix

Top expressed in

spermatocyte

hand

ventricular zone

genital tubercle

Rostral migratory stream

spermatid

ganglionic eminence

dentate gyrus of hippocampal formation granule cell

lumbar subsegment of spinal cord

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	GTPase regulator activity GTPase activator activity GTPase activity
Cellular component	cytoplasm cell projection nuclear matrix synapse condensed nuclear chromosome cell junction dendrite plasma membrane nucleus nucleolus cytosol
Biological process	regulation of G protein-coupled receptor signaling pathway transcription, DNA-templated positive regulation of GTPase activity negative regulation of signal transduction signal transduction regulation of catalytic activity G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6002


71729

Ensembl


ENSG00000159788


ENSMUSG00000029101

UniProt


O14924


Q8CGE9

RefSeq (mRNA)

NM_002926 NM_198227 NM_198229 NM_198230 NM_198430
NM_198432 NM_198587 NM_001394154 NM_001394155 NM_001394156 NM_001394157 NM_001394158 NM_001394159 NM_001394161 NM_001394162 NM_001394163


NM_001163512 NM_173402

RefSeq (protein)


NP_002917 NP_937870 NP_937872

NP_001156984 NP_775578 NP_001390400 NP_001390401 NP_001390402
NP_001390403 NP_001390404 NP_001390405 NP_001390406 NP_001390407

Location (UCSC)

Chr 4: 3.29 – 3.44 Mb

Chr 5: 35.11 – 35.2 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.^[5]^[6]

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.^[6]

Interactions

RGS12 has been shown to interact with GNAI1,^[7] GNAI3,^[7] and the kappa opioid receptor.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159788 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029101 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.
^ ^a ^b "Entrez Gene: RGS12 regulator of G-protein signalling 12".
^ ^a ^b Kimple RJ, De Vries L, Tronchère H, Behe C I, Morris R A, Gist Farquhar M, Siderovski D P (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333.
^ Gross JD, Kaski SW, Schmidt KT, Cogan ES, Boyt KM, Wix K, Schroer AB, McElligott ZA, Siderovski DP, Setola V (September 2019). "Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior". Neuropsychopharmacology. 44 (10): 1728–1741. doi:10.1038/s41386-019-0423-7. PMC 6785087. PMID 31141817.

Frohme M, Scharm B, Delius H, et al. (2000). "Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue". Ann. N. Y. Acad. Sci. 910 (1): 85–104, discussion 104–5. Bibcode:2000NYASA.910...85F. doi:10.1111/j.1749-6632.2000.tb06703.x. PMID 10911908. S2CID 25399395.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Snow BE, Antonio L, Suggs S, et al. (1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14". Biochem. Biophys. Res. Commun. 233 (3): 770–7. doi:10.1006/bbrc.1997.6537. PMID 9168931.
Chatterjee TK, Fisher RA (2000). "Novel alternative splicing and nuclear localization of human RGS12 gene products". J. Biol. Chem. 275 (38): 29660–71. doi:10.1074/jbc.M000330200. PMID 10869340.
Schiff ML, Siderovski DP, Jordan JD, et al. (2001). "Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel". Nature. 408 (6813): 723–7. doi:10.1038/35047093. PMID 11130074. S2CID 205011654.
Kimple RJ, De Vries L, Tronchère H, et al. (2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
Snow BE, Brothers GM, Siderovski DP (2002). "Molecular Cloning of Regulators of G-Protein Signaling Family Members and Characterization of Binding Specificity of RGS 12 PDZ Domain". G Protein Pathways, Part B: G Proteins and their Regulators. Methods in Enzymology. Vol. 344. pp. 740–61. doi:10.1016/S0076-6879(02)44752-0. ISBN 978-0-12-182245-3. PMID 11771424.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488. S2CID 16065132.
Chatterjee TK, Fisher RA (2002). "RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression". Mol. Cell. Biol. 22 (12): 4334–45. doi:10.1128/MCB.22.12.4334-4345.2002. PMC 133853. PMID 12024043.
Potocnik U, Glavac D, Ravnik-Glavac M (2003). "Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability". Genes Chromosomes Cancer. 36 (1): 48–56. doi:10.1002/gcc.10141. PMID 12461749. S2CID 30132562.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Yang S, Li YP (2007). "RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro". J. Bone Miner. Res. 22 (1): 45–54. doi:10.1359/jbmr.061007. PMC 3559086. PMID 17042716.
Gross JD, Kaski SW, Schroer AB, Wix KA, Siderovski DP, Setola V (2018). "Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants". J. Psychopharmacol. 32 (2): 191–203. doi:10.1177/0269881117742100. PMC 5942192. PMID 29364035.
Gross JD, Kaski SW, Schmidt KT, Cogan ES, Boyt KM, Wix K, Schroer AB, McElligott ZA, Siderovski DP (2019-05-29). "Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior". Neuropsychopharmacology. 44 (10): 1728–1741. doi:10.1038/s41386-019-0423-7. ISSN 1740-634X. PMC 6785087. PMID 31141817.
Schroer AB, Mohamed JS, Willard MD, Setola V, Oestreich E, Siderovski DP (2019). "A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation". PLOS ONE. 14 (8): e0216167. Bibcode:2019PLoSO..1416167S. doi:10.1371/journal.pone.0216167. PMC 6691989. PMID 31408461.