RGS3

Protein-coding gene in the species Homo sapiens

RGS3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2F5Y, 2OJ4, 3FBK

Identifiers

Aliases

RGS3, C2PA, RGP3, regulator of G-protein signaling 3, regulator of G protein signaling 3

External IDs

OMIM: 602189; MGI: 1354734; HomoloGene: 32440; GeneCards: RGS3; OMA:RGS3 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q32	Start	113,444,731 bp^[1]
Band	9q32	End	113,597,743 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 B3\|4 33.19 cM	Start	62,478,084 bp^[2]
Band	4 B3\|4 33.19 cM	End	62,622,238 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

apex of heart

cartilage tissue

periodontal fiber

ascending aorta

Descending thoracic aorta

left ventricle

gallbladder

right auricle

lateral nuclear group of thalamus

granulocyte

Top expressed in

zygote

granulocyte

ventricular zone

genital tubercle

secondary oocyte

external carotid artery

internal carotid artery

spermatid

yolk sac

neural layer of retina

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding GTPase activator activity GTPase activity
Cellular component	plasma membrane membrane nucleus nucleoplasm cytosol cytoplasm
Biological process	negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of GTPase activity G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5998


50780

Ensembl


ENSG00000138835


ENSMUSG00000059810

UniProt


P49796


Q9DC04

RefSeq (mRNA)

NM_001276260 NM_001276261 NM_001276262 NM_001282922 NM_001282923
NM_017790 NM_130795 NM_134427 NM_144488 NM_144489 NM_001322214 NM_001322215 NM_001351526 NM_001394167


NM_001081650 NM_019492 NM_134257 NM_001310706

RefSeq (protein)

NP_001263189 NP_001263190 NP_001263191 NP_001269851 NP_001269852
NP_001309143 NP_001309144 NP_060260 NP_570613 NP_602299 NP_652759 NP_652760 NP_001338455 NP_001263189.1 NP_001269851.1


NP_001075119 NP_001297635 NP_062365 NP_599018

Location (UCSC)

Chr 9: 113.44 – 113.6 Mb

Chr 4: 62.48 – 62.62 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.^[5]^[6]^[7]

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138835 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059810 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–6. Bibcode:1996Natur.379..742D. doi:10.1038/379742a0. PMID 8602223. S2CID 4362632.
^ Linares JL, Wendling C, Tomasetto C, Rio MC (Nov 2000). "C2PA, a new protein expressed during mouse spermatogenesis". FEBS Lett. 480 (2–3): 249–54. doi:10.1016/S0014-5793(00)01942-6. PMID 11034339. S2CID 12703563.
^ ^a ^b "Entrez Gene: RGS3 regulator of G-protein signalling 3".

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Chatterjee TK, Eapen A, Kanis AB, Fisher RA (1998). "Genomic organization, 5'-flanking region, and chromosomal localization of the human RGS3 gene". Genomics. 45 (2): 429–33. doi:10.1006/geno.1997.4929. PMID 9344672.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
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Mittmann C, Schüler C, Chung CH, Not Available NA, Not Available NA, Not Available NA, Not Available NA (2001). "Evidence for a short form of RGS3 preferentially expressed in the human heart". Naunyn-Schmiedeberg's Arch. Pharmacol. 363 (4): 456–63. doi:10.1007/s002100000376. PMID 11330340. S2CID 36657400.
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Hirabayashi S, Ohno H, Iida J, Hata Y (2003). "C2PA is a nuclear protein implicated in the heat shock response". J. Cell. Biochem. 87 (1): 65–74. doi:10.1002/jcb.10279. PMID 12210723. S2CID 45812827.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
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Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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