TRIP10

Protein-coding gene in the species Homo sapiens

TRIP10

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2CT4, 2EFK, 2KE4

Identifiers

Aliases

TRIP10, CIP4, HSTP, STOT, STP, TRIP-10, thyroid hormone receptor interactor 10

External IDs

OMIM: 604504; MGI: 2146901; HomoloGene: 99728; GeneCards: TRIP10; OMA:TRIP10 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	6,737,925 bp^[1]
Band	19p13.3	End	6,751,530 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 D	Start	57,556,455 bp^[2]
Band	17\|17 D	End	57,570,665 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

muscle of thigh

gastrocnemius muscle

gastric mucosa

apex of heart

ectocervix

Descending thoracic aorta

muscle layer of sigmoid colon

right coronary artery

ascending aorta

right ovary

Top expressed in

interventricular septum

muscle of thigh

skeletal muscle tissue

triceps brachii muscle

temporal muscle

ankle

sternocleidomastoid muscle

extraocular muscle

digastric muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding identical protein binding lipid binding GTPase activator activity
Cellular component	cytoplasm cytosol Golgi apparatus cell projection intracellular membrane-bounded organelle membrane plasma membrane nucleoplasm cell cortex perinuclear region of cytoplasm lysosome phagocytic cup cytoskeleton extracellular exosome
Biological process	endocytosis cell communication regulation of small GTPase mediated signal transduction signal transduction positive regulation of GTPase activity actin cytoskeleton organization membrane organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9322


106628

Ensembl


ENSG00000125733


ENSMUSG00000019487

UniProt


Q15642


Q8CJ53

RefSeq (mRNA)


NM_001288962 NM_001288963 NM_004240


NM_001242389 NM_001242390 NM_001242391 NM_134125

RefSeq (protein)


NP_001275891 NP_001275892 NP_004231


NP_001229318 NP_001229319 NP_001229320 NP_598886

Location (UCSC)

Chr 19: 6.74 – 6.75 Mb

Chr 17: 57.56 – 57.57 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene.^[5]^[6]^[7]^[8]

Interactions

TRIP10 has been shown to interact with STAT3,^[9] Wiskott-Aldrich syndrome protein,^[10] Huntingtin,^[11] CDC42,^[6]^[10] AKAP9^[12] and RHOQ.^[13]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125733 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019487 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.
^ ^a ^b Aspenstrom P (August 1997). "A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton". Curr Biol. 7 (7): 479–87. doi:10.1016/S0960-9822(06)00219-3. PMID 9210375. S2CID 14268690.
^ Tsuji E, Tsuji Y (April 2001). "Molecular cloning and chromosomal localization of human salt-tolerant protein". Genetica. 108 (3): 259–62. doi:10.1023/A:1004132919896. PMID 11294612. S2CID 22725257.
^ "Entrez Gene: TRIP10 thyroid hormone receptor interactor 10".
^ Chung, Young-Hwa; Cho Nam-hyuk; Garcia Maria Ines; Lee Sun-Hwa; Feng Pinghui; Jung Jae U (June 2004). "Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein". J. Virol. 78 (12). United States: 6489–97. doi:10.1128/JVI.78.12.6489-6497.2004. ISSN 0022-538X. PMC 416526. PMID 15163742.
^ ^a ^b Tian, L; Nelson D L; Stewart D M (March 2000). "Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules". J. Biol. Chem. 275 (11). UNITED STATES: 7854–61. doi:10.1074/jbc.275.11.7854. ISSN 0021-9258. PMID 10713100.
^ Holbert, Sébastien; Dedeoglu Alpaslan; Humbert Sandrine; Saudou Frédéric; Ferrante Robert J; Néri Christian (March 2003). "Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease". Proc. Natl. Acad. Sci. U.S.A. 100 (5). United States: 2712–7. Bibcode:2003PNAS..100.2712H. doi:10.1073/pnas.0437967100. ISSN 0027-8424. PMC 151406. PMID 12604778.
^ Larocca, M Cecilia; Shanks Ryan A; Tian Lan; Nelson David L; Stewart Donn M; Goldenring James R (June 2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus". Mol. Biol. Cell. 15 (6). United States: 2771–81. doi:10.1091/mbc.E03-10-0757. ISSN 1059-1524. PMC 420101. PMID 15047863.
^ Chang, Louise; Adams Rachael D; Saltiel Alan R (October 2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. 99 (20). United States: 12835–40. Bibcode:2002PNAS...9912835C. doi:10.1073/pnas.202495599. ISSN 0027-8424. PMC 130546. PMID 12242347.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Tian L, Nelson DL, Stewart DM (2000). "Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules". J. Biol. Chem. 275 (11): 7854–61. doi:10.1074/jbc.275.11.7854. PMID 10713100.
Linder S, Hüfner K, Wintergerst U, Aepfelbacher M (2001). "Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages". J. Cell Sci. 113 Pt 23 (23): 4165–76. doi:10.1242/jcs.113.23.4165. PMID 11069762.
Richnau N, Aspenström P (2001). "Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1". J. Biol. Chem. 276 (37): 35060–70. doi:10.1074/jbc.M103540200. PMID 11431473.
Yuan R, Fan S, Achary M, et al. (2001). "Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage". Cancer Res. 61 (21): 8022–31. PMID 11691828.
Wang L, Rudert WA, Grishin A, et al. (2002). "Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms". Biochem. Biophys. Res. Commun. 293 (5): 1426–30. doi:10.1016/S0006-291X(02)00398-4. PMID 12054674.
Chang L, Adams RD, Saltiel AR (2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12835–40. Bibcode:2002PNAS...9912835C. doi:10.1073/pnas.202495599. PMC 130546. PMID 12242347.
Dombrosky-Ferlan P, Grishin A, Botelho RJ, et al. (2003). "Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup". Blood. 101 (7): 2804–9. doi:10.1182/blood-2002-03-0851. PMID 12456510.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Holbert S, Dedeoglu A, Humbert S, et al. (2003). "Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2712–7. Bibcode:2003PNAS..100.2712H. doi:10.1073/pnas.0437967100. PMC 151406. PMID 12604778.
Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID 12736724.
Morin F, Vannier B, Houdart F, et al. (2003). "A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins". Mol. Vis. 9: 449–59. PMID 14502124.
Larocca MC, Shanks RA, Tian L, et al. (2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus". Mol. Biol. Cell. 15 (6): 2771–81. doi:10.1091/mbc.E03-10-0757. PMC 420101. PMID 15047863.
Chung YH, Cho NH, Garcia MI, et al. (2004). "Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein". J. Virol. 78 (12): 6489–97. doi:10.1128/JVI.78.12.6489-6497.2004. PMC 416526. PMID 15163742.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yin X, Warner DR, Roberts EA, et al. (2005). "Identification of novel CBP interacting proteins in embryonic orofacial tissue". Biochem. Biophys. Res. Commun. 329 (3): 1010–7. doi:10.1016/j.bbrc.2005.02.075. PMID 15752756.

PDB gallery

2ct4: Solution structure of the SH3 domain of the Cdc42-interacting protein 4
2efk: Crystal structure of the EFC domain of Cdc42-interacting protein 4