Trimethylsilylpropanoic acid

Trimethylsilylpropanoic acid
Skeletal formula of TMSP
Ball-and-stick model of the TMSP molecule
Names
Preferred IUPAC name
3-(Trimethylsilyl)propanoic acid
Other names
3-Trimethylsilylpropanoate; 3-(Trimethylsilyl)propionic acid; 2,2-Dimethyl-2-silapentan-5-oic acid
Identifiers
CAS Number
  • 5683-30-7 checkY
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:85487 checkY
ChemSpider
  • 72062
ECHA InfoCard 100.024.678 Edit this at Wikidata
PubChem CID
  • 79764
UNII
  • X8H75Z8P93 checkY
CompTox Dashboard (EPA)
  • DTXSID7063978 Edit this at Wikidata
InChI
  • InChI=1S/C6H14O2Si/c1-9(2,3)5-4-6(7)8/h4-5H2,1-3H3,(H,7,8)
  • O=C(O)CC[Si](C)(C)C
Properties
Chemical formula
 C6H14O2Si (acid), C6H13O2Si− (anion)
Molar mass 146.26 g/mol (acid), 145.25 g/mol (anion), 172.27 g/mol (sodium salt of deuterated molecule)
Appearance Colorless liquid
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound

Trimethylsilylpropanoic acid (TMSP or TSP) is a chemical compound containing a trimethylsilyl group. It is used as internal reference in nuclear magnetic resonance for aqueous solvents (e.g. D2O). For that use it is often deuterated (3-(trimethylsilyl)-2,2,3,3-tetradeuteropropionic acid or TMSP-d4).[1] Other internal references that are frequently used in NMR experiments are DSS and tetramethylsilane.

Deuterated TMSP sodium salt

References

  1. ^ Pohl, L.; Eckle, M. (1969). "Sodium 3-(trimethylsilyl)tetradeuteriopropionate, a new water-soluble standard for 1H NMR". Angewandte Chemie International Edition in English. 8 (5): 381. doi:10.1002/anie.196903811.


  • v
  • t
  • e
Stub icon

This nuclear magnetic resonance–related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e