UCHL3

Enzyme in humans encoded by the UCHL3 gene
UCHL3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1UCH, 1XD3

Identifiers
AliasesUCHL3, UCH-L3, ubiquitin C-terminal hydrolase L3
External IDsOMIM: 603090; MGI: 1355274; HomoloGene: 4377; GeneCards: UCHL3; OMA:UCHL3 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for UCHL3
Genomic location for UCHL3
Band13q22.2Start75,549,480 bp[1]
End75,606,020 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for UCHL3
Genomic location for UCHL3
Band14 E2.3|14 50.9 cMStart101,891,403 bp[2]
End101,933,561 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right adrenal gland

  • right adrenal cortex

  • left adrenal gland

  • islet of Langerhans

  • left adrenal cortex

  • mucosa of esophagus

  • rectum

  • skin of leg

  • gastrocnemius muscle

  • skin of abdomen
Top expressed in
  • left ventricle

  • interventricular septum

  • spermatid

  • epiblast

  • embryo

  • spermatocyte

  • neural tube

  • esophagus

  • placenta

  • mesencephalon
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • cysteine-type peptidase activity
  • hydrolase activity
  • peptidase activity
  • ubiquitin binding
  • NEDD8-specific protease activity
  • thiol-dependent deubiquitinase
Cellular component
  • nucleus
  • intracellular anatomical structure
  • cytoplasm
  • cytosol
Biological process
  • protein catabolic process
  • proteolysis
  • ubiquitin-dependent protein catabolic process
  • post-translational protein modification
  • protein deubiquitination
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7347

50933

Ensembl

ENSG00000118939

ENSMUSG00000022111

UniProt

P15374

Q9JKB1

RefSeq (mRNA)

NM_001270952
NM_006002

NM_016723

RefSeq (protein)

NP_001257881
NP_005993

NP_057932

Location (UCSC)Chr 13: 75.55 – 75.61 MbChr 14: 101.89 – 101.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase isozyme L3 is an enzyme that in humans is encoded by the UCHL3 gene.[5][6]

Interactions

UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule UBB+1.[7][8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118939 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022111 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J (Dec 1989). "The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase". Science. 246 (4930): 670–3. Bibcode:1989Sci...246..670W. doi:10.1126/science.2530630. PMID 2530630.
  6. ^ "Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)".
  7. ^ Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW (July 2011). "Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)". FEBS Lett. 585 (16): 2568–74. doi:10.1016/j.febslet.2011.06.037. PMID 21762696. S2CID 28207136.
  8. ^ Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T (October 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochem. Biophys. Res. Commun. 251 (3): 688–92. doi:10.1006/bbrc.1998.9532. PMID 9790970.

Further reading

  • Johnston SC, Larsen CN, Cook WJ, et al. (1997). "Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution". EMBO J. 16 (13): 3787–96. doi:10.1093/emboj/16.13.3787. PMC 1170002. PMID 9233788.
  • Wilkinson KD, Laleli-Sahin E, Urbauer J, et al. (1999). "The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3". J. Mol. Biol. 291 (5): 1067–77. doi:10.1006/jmbi.1999.3038. PMID 10518943.
  • Baek SH, Yoo YJ, Tanaka K, Chung CH (1999). "Molecular cloning of chick UCH-6 which shares high similarity with human UCH-L3: its unusual substrate specificity and tissue distribution". Biochem. Biophys. Res. Commun. 264 (1): 235–40. doi:10.1006/bbrc.1999.1492. PMID 10527871.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Saito S, Iida A, Sekine A, et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population". J. Hum. Genet. 48 (5): 249–70. doi:10.1007/s10038-003-0021-7. PMID 12721789.
  • Nam MJ, Madoz-Gurpide J, Wang H, et al. (2004). "Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3". Proteomics. 3 (11): 2108–15. doi:10.1002/pmic.200300594. PMID 14595809. S2CID 27511690.
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Misaghi S, Galardy PJ, Meester WJ, et al. (2005). "Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate". J. Biol. Chem. 280 (2): 1512–20. doi:10.1074/jbc.M410770200. PMID 15531586.
  • Rolén U, Kobzeva V, Gasparjan N, et al. (2006). "Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines". Mol. Carcinog. 45 (4): 260–9. doi:10.1002/mc.20177. PMID 16402389. S2CID 6633207.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • v
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  • 1uch: DEUBIQUITINATING ENZYME UCH-L3 (HUMAN) AT 1.8 ANGSTROM RESOLUTION
    1uch: DEUBIQUITINATING ENZYME UCH-L3 (HUMAN) AT 1.8 ANGSTROM RESOLUTION
  • 1xd3: Crystal structure of UCHL3-UbVME complex
    1xd3: Crystal structure of UCHL3-UbVME complex


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