XAB2

Protein-coding gene in the species Homo sapiens

XAB2

Identifiers

Aliases

XAB2, HCNP, HCRN, NTC90, SYF1, XPA binding protein 2

External IDs

OMIM: 610850; MGI: 1914689; HomoloGene: 5738; GeneCards: XAB2; OMA:XAB2 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.2	Start	7,619,525 bp^[1]
Band	19p13.2	End	7,629,545 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8 A1.1\|8 1.92 cM	Start	3,658,421 bp^[2]
Band	8 A1.1\|8 1.92 cM	End	3,671,316 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

left ovary

granulocyte

right ovary

skin of leg

body of uterus

right uterine tube

canal of the cervix

right lobe of thyroid gland

left lobe of thyroid gland

skin of abdomen

Top expressed in

gastrula

submandibular gland

internal carotid artery

external carotid artery

Rostral migratory stream

Gonadal ridge

vestibular membrane of cochlear duct

maxillary prominence

epiblast

granulocyte

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	catalytic step 2 spliceosome membrane nucleoplasm spliceosomal complex nucleus Prp19 complex prespliceosome catalytic step 1 spliceosome post-mRNA release spliceosomal complex U2-type catalytic step 2 spliceosome
Biological process	RNA processing mRNA processing transcription, DNA-templated cellular response to DNA damage stimulus RNA splicing cerebral cortex development transcription-coupled nucleotide-excision repair blastocyst development DNA repair mRNA splicing, via spliceosome generation of catalytic spliceosome for first transesterification step
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


56949


67439

Ensembl


ENSG00000076924


ENSMUSG00000019470

UniProt


Q9HCS7


Q9DCD2

RefSeq (mRNA)


NM_020196


NM_026156

RefSeq (protein)


NP_064581


NP_080432

Location (UCSC)

Chr 19: 7.62 – 7.63 Mb

Chr 8: 3.66 – 3.67 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Pre-mRNA-splicing factor SYF1 is a protein that in humans is encoded by the XAB2 gene.^[5]^[6]

Interactions

XAB2 has been shown to interact with ERCC8^[5] and XPA.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076924 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019470 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo JP, Khaw MC, Saijo M, Kodo N, Matsuda T, Hoeijmakers JH, Tanaka K (Nov 2000). "XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription". J. Biol. Chem. 275 (45): 34931–7. doi:10.1074/jbc.M004936200. hdl:1765/3168. PMID 10944529.
^ "Entrez Gene: XAB2 XPA binding protein 2".

Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.