YTHDF2

Protein-coding gene in humans
YTHDF2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4RDN, 4RDO, 4WQN

Identifiers
AliasesYTHDF2, HGRG8, NY-REN-2, CAHL, YTH N6-methyladenosine RNA binding protein 2, DF2
External IDsOMIM: 610640; MGI: 2444233; HomoloGene: 32302; GeneCards: YTHDF2; OMA:YTHDF2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for YTHDF2
Genomic location for YTHDF2
Band1p35.3Start28,736,621 bp[1]
End28,769,775 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for YTHDF2
Genomic location for YTHDF2
Band4|4 D2.3Start131,912,223 bp[2]
End131,939,614 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • cerebellar vermis

  • quadriceps femoris muscle

  • ganglionic eminence

  • islet of Langerhans

  • stromal cell of endometrium

  • bone marrow cells

  • olfactory zone of nasal mucosa

  • skin of abdomen

  • ventricular zone
Top expressed in
  • maxillary prominence

  • medial ganglionic eminence

  • mandibular prominence

  • hand

  • abdominal wall

  • cumulus cell

  • endocardial cushion

  • vas deferens

  • somite

  • epiblast
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • N6-methyladenosine-containing RNA binding
  • protein binding
  • RNA binding
Cellular component
  • cytosol
  • P-body
  • nucleus
  • cytoplasm
  • microtubule organizing center
  • cytoplasmic ribonucleoprotein granule
Biological process
  • humoral immune response
  • positive regulation of cap-independent translational initiation
  • regulation of mRNA stability
  • embryonic morphogenesis
  • mRNA destabilization
  • oocyte maturation
  • negative regulation of Notch signaling pathway
  • endothelial to hematopoietic transition
  • regulation of hematopoietic stem cell differentiation
  • regulation of meiotic cell cycle process involved in oocyte maturation
  • cell differentiation
  • oogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51441

213541

Ensembl

ENSG00000198492

ENSMUSG00000040025

UniProt

Q9Y5A9

Q91YT7

RefSeq (mRNA)

NM_016258
NM_001172828
NM_001173128

NM_145393

RefSeq (protein)

NP_001166299
NP_001166599
NP_057342

NP_663368

Location (UCSC)Chr 1: 28.74 – 28.77 MbChr 4: 131.91 – 131.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

YTH N6-methyladenosine RNA binding protein 2 is a protein that in humans is encoded by the YTHDF2 gene. [5]

Function

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline-rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. Also, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively, spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012].

See also

N6-Methyladenosine

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198492 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040025 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: YTH N6-methyladenosine RNA binding protein 2". Retrieved 2017-12-24.

Further reading

  • Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
  • Cardelli M, Marchegiani F, Cavallone L, Olivieri F, Giovagnetti S, Mugianesi E, Moresi R, Lisa R, Franceschi C (2006). "A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity". J. Gerontol. A Biol. Sci. Med. Sci. 61 (6): 547–56. doi:10.1093/gerona/61.6.547. PMID 16799135.
  • Cardelli M, Marchegiani F, Cavallone L, Olivieri F, Giovagnetti S, Mugianesi E, Moresi R, Lisa R, Franceschi C (2006). "A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity". J. Gerontol. A Biol. Sci. Med. Sci. 61 (6): 547–56. doi:10.1093/gerona/61.6.547. PMID 16799135.
  • Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C (2014). "N6-methyladenosine-dependent regulation of messenger RNA stability". Nature. 505 (7481): 117–20. Bibcode:2014Natur.505..117W. doi:10.1038/nature12730. PMC 3877715. PMID 24284625.
  • Li F, Zhao D, Wu J, Shi Y (2014). "Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition". Cell Res. 24 (12): 1490–2. doi:10.1038/cr.2014.153. PMC 4260351. PMID 25412658.
  • Zhu T, Roundtree IA, Wang P, Wang X, Wang L, Sun C, Tian Y, Li J, He C, Xu Y (2014). "Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine". Cell Res. 24 (12): 1493–6. doi:10.1038/cr.2014.152. PMC 4260350. PMID 25412661.
  • Xu C, Liu K, Ahmed H, Loppnau P, Schapira M, Min J (2015). "Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins". J. Biol. Chem. 290 (41): 24902–13. doi:10.1074/jbc.M115.680389. PMC 4598999. PMID 26318451.
  • Tirumuru N, Zhao BS, Lu W, Lu Z, He C, Wu L (2016). "N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression". eLife. 5. doi:10.7554/eLife.15528. PMC 4961459. PMID 27371828.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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