ZFP161

Protein-coding gene in the species Homo sapiens
ZBTB14
Identifiers
AliasesZBTB14, ZF5, ZFP-161, ZFP-5, ZFP161, ZNF478, zinc finger and BTB domain containing 14
External IDsOMIM: 602126; MGI: 1195345; HomoloGene: 2560; GeneCards: ZBTB14; OMA:ZBTB14 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for ZBTB14
Genomic location for ZBTB14
Band18p11.31Start5,289,019 bp[1]
End5,297,053 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for ZBTB14
Genomic location for ZBTB14
Band17 E1.3|17 40.42 cMStart69,690,045 bp[2]
End69,698,194 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • lymph node

  • monocyte

  • granulocyte

  • ganglionic eminence

  • gallbladder

  • ventricular zone

  • C1 segment

  • gonad

  • rectum
Top expressed in
  • ureter

  • condyle

  • Paneth cell

  • ciliary body

  • fossa

  • medullary collecting duct

  • lacrimal gland

  • ascending aorta

  • cumulus cell

  • aortic valve
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • sequence-specific DNA binding
  • DNA binding
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
  • nucleolus
  • cytosol
  • aggresome
Biological process
  • cardiac septum development
  • heart valve development
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • coronary vasculature development
  • transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7541

22666

Ensembl

ENSG00000198081

ENSMUSG00000049672

UniProt

O43829

Q08376

RefSeq (mRNA)

NM_003409
NM_001143823
NM_001243702
NM_001243704

NM_009547
NM_001356282
NM_001356283

RefSeq (protein)

NP_001137295
NP_001230631
NP_001230633
NP_003400

NP_033573
NP_001343211
NP_001343212

Location (UCSC)Chr 18: 5.29 – 5.3 MbChr 17: 69.69 – 69.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 161 homolog is a protein that in humans is encoded by the ZBTB14 gene.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198081 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049672 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sobek-Klocke I, Disque-Kochem C, Ronsiek M, Klocke R, Jockusch H, Breuning A, Ponstingl H, Rojas K, Overhauser J, Eichenlaub-Ritter U (Sep 1997). "The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr)". Genomics. 43 (2): 156–64. doi:10.1006/geno.1997.4784. PMID 9244432.
  6. ^ "Entrez Gene: ZFP161 zinc finger protein 161 homolog (mouse)".

Further reading

  • Numoto M, Niwa O, Kaplan J, et al. (1993). "Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins". Nucleic Acids Res. 21 (16): 3767–75. doi:10.1093/nar/21.16.3767. PMC 309887. PMID 8367294.
  • Sugiura K, Muro Y, Nagai Y, et al. (1997). "Expression cloning and intracellular localization of a human ZF5 homologue". Biochim. Biophys. Acta. 1352 (1): 23–6. doi:10.1016/s0167-4781(97)00045-6. PMID 9177479.
  • Obata T, Yanagidani A, Yokoro K, et al. (1999). "Analysis of the consensus binding sequence and the DNA-binding domain of ZF5". Biochem. Biophys. Res. Commun. 255 (2): 528–34. doi:10.1006/bbrc.1998.9970. PMID 10049742.
  • Numoto M, Yokoro K, Koshi J (1999). "ZF5, which is a Kruppel-type transcriptional repressor, requires the zinc finger domain for self-association". Biochem. Biophys. Res. Commun. 256 (3): 573–8. doi:10.1006/bbrc.1999.0375. PMID 10080939.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lee KH, Kwak YD, Kim DH, et al. (2004). "Human zinc finger protein 161, a novel transcriptional activator of the dopamine transporter". Biochem. Biophys. Res. Commun. 313 (4): 969–76. doi:10.1016/j.bbrc.2003.11.183. PMID 14706637.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wang J, Kudoh J, Takayanagi A, Shimizu N (2005). "Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161". Biochem. Biophys. Res. Commun. 327 (2): 615–27. doi:10.1016/j.bbrc.2004.12.048. PMID 15629158.
  • Orlov SV, Kuteĭkin-Tepliakov KB, Grishin AV, et al. (2006). "[Transcription factor ZF5 regulates expression of mammalian gene containing GCC-triplet repeats in 5'-regulatory region in human hepatoma HepG2 cells]". Tsitologiia. 48 (3): 246–52. PMID 16805315.
  • Orlov SV, Kuteykin-Teplyakov KB, Ignatovich IA, et al. (2007). "Novel repressor of the human FMR1 gene - identification of p56 human (GCC)(n)-binding protein as a Krüppel-like transcription factor ZF5". FEBS J. 274 (18): 4848–62. doi:10.1111/j.1742-4658.2007.06006.x. PMID 17714511. S2CID 31019370.
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