Dimetilglicin

IUPAC ime


2-(Dimetilamino)sirćetna kiselina^[1]

Drugi nazivi

N,N-Dimetilglicin

Identifikacija

CAS registarski broj

1118-68-9^Y

PubChem^[2]^[3]

673

ChemSpider^[4]

653^Y

EINECS broj

214-267-8

DrugBank

DB02083

KEGG^[5]

C01026

MeSH

dimethylglycine

ChEBI

17724

RTECS registarski broj toksičnosti

MB9865000

Bajlštajn

1700261

Gmelin Referenca

82215

3DMet

B00224

Jmol-3D slike

Slika 1
Slika 2

SMILES

CN(C)Cc(:[o]):[oH]

CN(C)CC(O)=O

InChI
InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)^Y Kod: FFDGPVCHZBVARC-UHFFFAOYSA-N^Y

Svojstva

Molekulska formula

C₄H₉NO₂

Molarna masa

103.12 g mol⁻¹

Agregatno stanje

Beli kristali

Miris

Bez mirisa

Tačka topljenja

178-182 °C, 451-455 K, 352-360 °F

Opasnost

LD₅₀

>650 mg kg⁻¹ (oralno, pacov)

Srodna jedinjenja

Srodna alkanoinske kiseline

Sarkozin
Glikociamin
Kreatin
N-Metil-D-aspartinska kiselina
beta-Metilamino-L-alanin
Guanidinopropionska kiselina

Srodna jedinjenja

Dimetilacetamid

Y (šta je ovo?) (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Dimetilglicin (DMG) je derivat aminokiseline glicina sa strukturnom formulom (CH₃)₂NCH₂COOH. On je prisutan u pasulju i jetri. On se može formirati iz trimetilglicina nakon gubitka jedne od njegovih metil grupa. On je takođe nusproizvod metabolizma holina.

Upotrebe

Dimetilglicin je predložen za moguću primenu kao sredstvo za poboljšanje atletske performance, imunostimulant, i za tretman autizma, epilepsije, i mitohondrijalne bolesti.^[6]^[7] Objavljene studije su pokazale da nema znatne razlike imeđu tretmana autiyma DMG-om i placebom.^[8]^[9]

Reference

↑ „dimethylglycine - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 16. 9. 2004.. Identification. Pristupljeno 24. 4. 2012.
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ „Dimethylglycine”. About Herbs, Botanicals & Other Products. Memorial Sloan–Kettering Cancer Center. 8. 12. 2009..
↑ Chinnery P, Majamaa K, Turnbull D, Thorburn D (2006). „Treatment for mitochondrial disorders”. Cochrane Database of Systematic Reviews (Online) (1): CD004426. DOI:10.1002/14651858.CD004426.pub2. PMID 16437486.
↑ Bolman WM, Richmond JA (June 1999). „A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder”. Journal of Autism and Developmental Disorders 29 (3): 191–4. PMID 10425581.
↑ Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M (March 2001). „Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder”. Journal of Child Neurology 16 (3): 169–73. PMID 11305684.