Kvinapril

(IUPAC) ime

(3S)-2-[(2S)-2- {[(2S)-1-etoksi-1-okso-4-fenilbutan-2-il]amino}propanoil]-1,2,3,4-tetrahidroizohinolin-3-karboksilna kiselina

Klinički podaci

Robne marke

Accupril

AHFS/Drugs.com

Monografija

MedlinePlus

a692026

Identifikatori

CAS broj

85441-61-8

ATC kod

C09AA06

PubChem^[1]^[2]

54892

DrugBank

DB00881

ChemSpider^[3]

49565

UNII

RJ84Y44811^Y

KEGG^[4]

D03752^Y

ChEBI

CHEBI:8713^Y

ChEMBL^[5]

CHEMBL1592^Y

Hemijski podaci

Formula

C₂₅H₃₀N₂O₅

Mol. masa

438,516 g/mol

SMILES

eMolekuli & PubHem

InChI
InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1^Y Key: JSDRRTOADPPCHY-HSQYWUDLSA-N^Y

Farmakokinetički podaci

Vezivanje za proteine plazme

97%

Poluvreme eliminacije

2 sata

Farmakoinformacioni podaci

Trudnoća

Pravni status

℞ Prescription only

Način primene

Oralno

Kvinapril (Accupril) je inhibitor angiotenzin konvertujućeg enzima (ACE inhibitor) koji se koristi u tretmanu hipertenzije i zatajenja srca.

Farmakologija

Kvinapril je prolek. On se konvertuje u aktivni metabolit, kvinaprilat, u jetri.^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 izd.). New York: McGraw-Hill. ISBN 0-07-142280-3.