Receptor retinoinske kiseline beta

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Receptor retinoinske kiseline, beta

PDB slika je bazirana na 1xap.

Dostupne strukture

1dsz, 1hra, 1xap, 1xdk

Identifikatori

Simboli

RARB; HAP; NR1B2; RRB2

Vanjski ID

OMIM: 180220 MGI: 97857 HomoloGene: 68100 GeneCards: RARB Gene

Ontologija gena
Molekularna funkcija	• aktivnost transkripcionog faktora • aktivnost steroidnog hormon receptora • aktivnost receptora retinoinske kiseline • aktivnost receptora • vezivanje jona cinka • sekvenca-specifično DNK vezivanje • vezivanje metalnog jona
Celularna komponenta	• celularna komponenta • nukleus
Biološki proces	• transkripcija • regulacija transkripcije, DNK-zavisna • prenos signala

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

5915

218772

Ensembl

ENSG00000077092

ENSMUSG00000017491

UniProt

P10826

Q8K1P6

RefSeq (mRNA)

NM_000965

NM_011243

RefSeq (protein)

NP_000956

NP_035373

Lokacija (UCSC)

Chr 3:
25.19 - 25.61 Mb

Chr 14:
15.22 - 15.61 Mb

PubMed pretraga

[1]

[2]

Receptor retinoinske kiseline beta (RAR-beta), also known as NR1B2 (nuclear receptor subfamily 1, group B, member 2) is a nuclear receptor encoded by the RARB gene.^[1]

Ovaj gen kodira receptor retinoinske kiseline beta, koji je član tiroid-steroid hormon receptorske super-familije nuklearnih transkripcionih regulatora. Ovaj receptor je lokalizovan u citoplazmi i u sub-nuklearnim kompartmanima. On vezuje retinoinsku kiselinu, biološki aktivnu formu vitamina A čime posreduje ćelijsku signalizaciju embrionske morfogene, ćelijski rast i diferencijaciju. Smatra se da ovaj protein ograničava rast mnogih ćelijskih tipova putem regulacije izražavanja gena. Ovaj gen je prvo identifikovan kod hepatocelularnih karcinoma, kod kojih se on nalazi pored integracionog mesta hepatitis B virusa. Ovaj gen izražava najmanje dve transkriptne varijante; jedan dodatni transkript je bio opisan, ali puna dužina njegovog proteina nije bila određena.^[1]

Interakcije

Pokazano je da receptor retinoinske kiseline beta ima interakciju sa nuklearni receptor srodnim 1 proteinom.^[2]

Reference

↑ ^1,0 ^1,1 „Entrez Gene: RARB retinoic acid receptor, beta”.
↑ Perlmann, T; Jansson L (Apr 1995). „A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1”. Genes Dev. (UNITED STATES) 9 (7): 769–82. ISSN 0890-9369. PMID 7705655.

Literatura

Dejean A, de Thé H (1990). „Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma.”. Mol. Biol. Med. 7 (3): 213–22. PMID 2170809.
Sun SY (2004). „Retinoic acid receptor beta and colon cancer.”. Cancer Biol. Ther. 3 (1): 87–8. PMID 14726690.
Saba N, Jain S, Khuri F (2004). „Chemoprevention in lung cancer.”. Current problems in cancer 28 (5): 287–306. DOI:10.1016/j.currproblcancer.2004.05.005. PMID 15375805.
Klein O, Grignon Y, Civit T, et al. (2006). „[Methylation status of RARbeta gene promoter in low and high grade cerebral glioma. Comparison with normal tissue. Immuno-histochemical study of nuclear RARbeta expression in low and high grade cerebral glioma cells. Comparison with normal cells. 48 tumors]”. Neuro-Chirurgie 51 (3-4 Pt 1): 147–54. PMID 16389900.
Katahira M, Knegtel RM, Boelens R, et al. (1992). „Homo- and heteronuclear NMR studies of the human retinoic acid receptor beta DNA-binding domain: sequential assignments and identification of secondary structure elements.”. Biochemistry 31 (28): 6474–80. DOI:10.1021/bi00143a017. PMID 1321662.
Berrodin TJ, Marks MS, Ozato K, et al. (1992). „Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein.”. Mol. Endocrinol. 6 (9): 1468–78. DOI:10.1210/me.6.9.1468. PMID 1331778.
van der Leede BJ, Folkers GE, Kruyt FA, van der Saag PT (1992). „Genomic organization of the human retinoic acid receptor beta 2.”. Biochem. Biophys. Res. Commun. 188 (2): 695–702. DOI:10.1016/0006-291X(92)91112-4. PMID 1332705.
Prentice A, Matthews CJ, Thomas EJ, Redfern CP (1992). „The expression of retinoic acid receptors in cultured human endometrial stromal cells and effects of retinoic acid.”. Hum. Reprod. 7 (5): 692–700. PMID 1379266.
Shen S, Kruyt FA, den Hertog J, et al. (1992). „Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness.”. DNA Seq. 2 (2): 111–9. DOI:10.3109/10425179109039679. PMID 1663808.
de Thé H, Vivanco-Ruiz MM, Tiollais P, et al. (1990). „Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene.”. Nature 343 (6254): 177–80. DOI:10.1038/343177a0. PMID 2153268.
Hoffmann B, Lehmann JM, Zhang XK, et al. (1991). „A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter.”. Mol. Endocrinol. 4 (11): 1727–36. DOI:10.1210/mend-4-11-1727. PMID 2177841.
de Thé H, Marchio A, Tiollais P, Dejean A (1988). „A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma.”. Nature 330 (6149): 667–70. DOI:10.1038/330667a0. PMID 2825037.
Brand N, Petkovich M, Krust A, et al. (1988). „Identification of a second human retinoic acid receptor.”. Nature 332 (6167): 850–3. DOI:10.1038/332850a0. PMID 2833708.
Benbrook D, Lernhardt E, Pfahl M (1988). „A new retinoic acid receptor identified from a hepatocellular carcinoma.”. Nature 333 (6174): 669–72. DOI:10.1038/333669a0. PMID 2836738.
Mattei MG, de Thé H, Mattei JF, et al. (1988). „Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3.”. Hum. Genet. 80 (2): 189–90. DOI:10.1007/BF00702867. PMID 2844650.
Dejean A, Bougueleret L, Grzeschik KH, Tiollais P (1986). „Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma.”. Nature 322 (6074): 70–2. DOI:10.1038/322070a0. PMID 3014347.
Si SP, Tsou HC, Lee X, Peacocke M (1995). „Effect of cellular senescence and retinoic acid on the expression of cellular retinoic acid binding proteins in skin fibroblasts.”. Exp. Cell Res. 219 (1): 243–8. DOI:10.1006/excr.1995.1224. PMID 7628539.
Houle B, Pelletier M, Wu J, et al. (1994). „Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines.”. Cancer Res. 54 (2): 365–9. PMID 8275470.
Knegtel RM, Katahira M, Schilthuis JG, et al. (1993). „The solution structure of the human retinoic acid receptor-beta DNA-binding domain.”. J. Biomol. NMR 3 (1): 1–17. DOI:10.1007/BF00242472. PMID 8383553.

Vidi još

Receptor retinoinske kiseline

PDB Galerija

1dsz: Struktura RXR/RAR DNK-vezujućeg domena heterodimera u kompleksu sa DR1 responsivnim elementom retinoinske kiseline

1hra: Rešenje strukture ljudskog DNK-vezujućeg domena retinoinskog receptora beta

1xap: Struktura ligand vezujućeg domena retinoinskog receptora beta

1xdk: Kristalna struktura RAR-beta/RXR-alfa ligand vezujućeg domena heterodimera u kompleksu sa 9-cis retinoinskom kiselinom i fragmentom TRAP220 koaktivatora

Transkripcioni faktori i intracelularni receptori

(1) Osnovni domeni

(1.1) Osnovni leucin rajsferšlus (bZIP)	Aktivirajući transkripcioni faktor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NFIL3 • NRL • NRF1 • XBP1
(1.2) Osnovni heliks-petlja-heliks (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatorni faktori (MyoD, Myogenin, MYF5, MYF6) • Neurogenini (1, 2, 3) • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Pho4 • Scleraxis • TAL (1, 2) • Twist • USF1
(1.3) bHLH-ZIP	AP-4 • MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.4) NF-1	NFI (A, B, C, X) • SMAD (R-SMAD (1, 2, 3, 5, 9) - I-SMAD (6, 7) - 4)
(1.5) RF-X	RFX (1, 2, 3, 4, 5, ANK)
(1.6) Osnovni heliks-razmak-heliks (bHSH)	AP-2 (α, β, γ, δ, ε)

(2) Cink prst DNA-vezujući domeni

(2.1) Nuklearni receptor (Cys₄)	podfamilija 1 (Tiroidni hormon (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) podfamilija 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testikularni receptor (2, 4), TLX) podfamilija 3 (Steroidni hormon (Androgen, Estrogen (α, β), Glukokortikoid, Mineralokortikoid, Progesteron), Estrogen-vezani (α, β, γ)) podfamilija 4 NUR (NGFIB, NOR1, NURR1) • podfamilija 5 (LRH-1, SF1) • podfamilija 6 (GCNF) • podfamilija 0 (DAX1, SHP)
(2.2) Drugi Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3) • TRPS1
(2.3) Cys₂His₂	Generalni transkripcioni faktori (TFIIA, TFIIB, TFIID, TFIIE, TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 • BCL (6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • GFI1 • GLI-Kruppel familija (1, 2, 3, REST, S2, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17) • MTF1 • MYT1 • OSR1 • SP (1, 2, 4, 7) • WT1 • Zbtb7 (7A, 7B) • ZBTB (16, 17, 20, 32, 33, 40) • cink prst (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 649, 655)
(2.4) Cys₆	HIVEP1
(2.5) Naizmenična kompozicija	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Heliks-zavoj-heliks domeni

(3.1) Homeodomen	ARX • CDX (1, 2) • CRX • CUTL1 • DBX (1, 2) • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • IRX (1, 2, 3, 4, 5, 6, MKX) • LMX (1A, 1B) • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) • PBX (1, 2, 3) • PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) • PITX (1, 2, 3) • POU domen (PIT-1, BRN-3: A, B, C, Oktamer transkripcioni faktor: 1, 2, 3/4, 6, 7, 11) • OTX (1, 2) • PDX1 • ZEB (1, 2)
(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
(3.3) Fork glava / winged heliks	E2F (1, 2, 3, 4, 5) • FOX proteini (C1, C2, D3, E1, G1, H1, K2, L2, M1, N3, O1, O3, O4, P1, P2, P3)
(3.4) Faktori toplotnog šoka	HSF (1, 2, 4)
(3.5) Triptofan klasteri	ELF (2, 4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2, SPIB) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatorni faktori (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domen	transkripcioni pojačivač faktor (1, 2, 3, 4)

(4) β-Scaffold faktori sa manjim žljebnim kontaktima

(4.1) Rel homologni region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)
(4.3) p53	p53 • TBX (1, 2, 3, 5, 19, 21, 22, Brahiuri, TBR1)
(4.4) MADS kutija	Mef2 (A, B, C, D) • SRF
(4.6) TATA vezujući proteini	TBP • TBPL1
(4.7) Grupa visoke pokretljivosti	HMGB (1, 2, 3) • HNF (1A, 1B) • LEF1 • SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) • SRY • SSRP1 • TCF (3, 4) • TOX (1, 2, 3, 4)
(4.10) Domen hladnog šoka	CSDA, YBX1
(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Drugi transkripcioni faktori

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1
(0.3) Džep domen	Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-vezani faktori	Apetala 2 • EREBP • B3
(0.6) Razno	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFY (A, B, C) • Ro/Sigma