Koagulacioni faktor IXa

Koagulacioni faktor IXa
Identifikatori
EC broj3.4.21.22
CAS broj37316-87-3
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
Pretraga
PMCčlanci
PubMedčlanci
NCBIproteini

Koagulacioni faktor IXa (EC 3.4.21.22, krvno koagulacioni faktor IXa, aktivirnai krvno koagulacioni faktor IX, autoprotrombin II, krvno trombinski kofaktor II, aktivirani krvno koagulacioni faktor XI) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Selektivno razlaganje Arg-Ile veze u faktoru X čime se formira faktor Xa

Ovaj enzim je himotripsinski homolog.

Reference

  1. ^ Fujikawa, K. & Davie, E.W. (1976). „Bovine factor IX (Christmas factor)”. Methods Enzymol. 45: 74—83. PMID 1012029. 
  2. ^ Davie, E.W.; Fujikawa, K.; Kurachi, K. & Kisiel, W. (1979). „The role of serine proteases in the blood coagulation cascade”. Adv. Enzymol. 48: 277—318. PMID 367103. 
  3. ^ Link, R.P. & Castellino, F.J. (1983). „Kinetic comparison of bovine blood coagulation factor IXaα and IXaβ towards bovine factor X”. Biochemistry. 22: 4033—4041. PMID 6412750. 
  4. ^ Cho, K.; Tanaka, T.; Cook, R.R.; Kisiel, W.; Fujikawa, K.; Kurachi, K. & Powers, J.C. (1984). „Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates”. Biochemistry. 23: 644—650. PMID 6370301. 

Literatura

  • Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
  • William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

  • Coagulation+factor+IXa на US National Library of Medicine Medical Subject Headings (MeSH)
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Teme
Tipovi
  • B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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