Taligluceraza alfa

Taligluceraza alfa
Klinički podaci
Prodajno ime	Elelyso, UPLYSO
Drugs.com	alfa.html Monografija
Način primene	Intravenozno
Farmakokinetički podaci
Poluvreme eliminacije	18,9 - 28,7 min

Identifikatori
CAS broj	37228-64-1^Y
ATC kod	A16AB11 (WHO)
DrugBank	DB08876^Y

Taligluceraza alfa (Elelyso) enzim je koji se proizvodi koristeći biljne ćelije.^[1] Ovaj enzim je rekombinantna glukocerebrozidaza, koja se koristi za lečenje Gaučeve bolesti.^[2]^[3]^[4]^[5] Ona je bila prvi lek biljnog porekla koji je FDA odobrila.^[6]^[7] Izražavanje proteina u biljnim ćelijama je dovoljno visoko da nisu neophodna naknadne modifikacije proteina. Produkt nije podložan virusnoj kontaminaciji. Upotreva transgenskih ćelija šargarepe je jeftinija alternativa. Preklinička ispitivanja su pokazala da je enzim dobro tolerisan kod pacijenata.^[8]

Reference

^ Expanded Access Trial of Plant Expressed Recombinant Glucocerebrosidase (prGCD) in Patients With Gaucher Disease
^ Zimran A, Brill-Almon E, Chertkoff R, Petakov M, Blanco-Favela F, Munoz ET, Solorio-Meza SE, Amato D, Duran G, Giona F, Heitner R, Rosenbaum H, Giraldo P, Mehta A, Park G, Phillips M, Elstein D, Altarescu G, Szleifer M, Hashmueli S, Aviezer D: Pivotal trial with plant cell-expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease. Blood. 2011 Nov 24;118(22):5767-73. doi: 10.1182/blood-2011-07-366955. Epub 2011 Sep 6. PMID 21900191
^ Aviezer D, Brill-Almon E, Shaaltiel Y, Hashmueli S, Bartfeld D, Mizrachi S, Liberman Y, Freeman A, Zimran A, Galun E: A plant-derived recombinant human glucocerebrosidase enzyme--a preclinical and phase I investigation. PLoS One. 2009;4(3):e4792. doi: 10.1371/journal.pone.0004792. Epub 2009 Mar 11. PMID 19277123
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. уреди
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. уреди
^ Is the Drought Over for Pharming
^ Maxmen, Amy (2 may 2012) First plant-made drug on the market Архивирано на сајту Wayback Machine (18. октобар 2012) Nature, Biology & Biotechnology, Industry, Retrieved 26 June 2012
^ Aviezer, D; Brill-Almon, E; Shaaltiel, Y; Hashmueli, S; Bartfeld, D; Mizrachi, S; Liberman, Y; Freeman, A; Zimran, A (2009). Ho, Paulo Lee, ур. „A Plant-Derived Recombinant Human Glucocerebrosidase Enzyme—A Preclinical and Phase I Investigation”. PLoS ONE. 4 (3): e4792. PMC 2652073 . PMID 19277123. doi:10.1371/journal.pone.0004792.

Literatura

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