ATP1A4

Protein-coding gene in the species Homo sapiens
ATP1A4
Identifiers
AliasesATP1A4, ATP1A1, ATP1AL2, ATPase Na+/K+ transporting subunit alpha 4
External IDsOMIM: 607321; MGI: 1351335; HomoloGene: 113769; GeneCards: ATP1A4; OMA:ATP1A4 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ATP1A4
Genomic location for ATP1A4
Band1q23.2Start160,151,586 bp[1]
End160,186,980 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ATP1A4
Genomic location for ATP1A4
Band1 H3|1 79.54 cMStart172,051,080 bp[2]
End172,085,981 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • seminal vesicula

  • gastrocnemius muscle

  • urinary bladder

  • lymph node

  • sural nerve

  • placenta

  • gallbladder

  • appendix

  • monocyte
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • skeletal muscle tissue

  • subcutaneous adipose tissue

  • white adipose tissue

  • temporal muscle

  • mammary gland

  • petrous part of the temporal bone

  • cochlea
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • P-type sodium:potassium-exchanging transporter activity
  • metal ion binding
  • hydrolase activity
  • ATP binding
  • P-type potassium transmembrane transporter activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • integral component of plasma membrane
  • sodium:potassium-exchanging ATPase complex
Biological process
  • flagellated sperm motility
  • establishment or maintenance of transmembrane electrochemical gradient
  • sodium ion transport
  • regulation of membrane potential
  • ion transport
  • potassium ion transport
  • regulation of cellular pH
  • spermatogenesis
  • fertilization
  • cellular sodium ion homeostasis
  • cellular potassium ion homeostasis
  • sodium ion export across plasma membrane
  • potassium ion import across plasma membrane
  • ion transmembrane transport
  • regulation of cardiac conduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

480

27222

Ensembl

ENSG00000132681

ENSMUSG00000007107

UniProt

Q13733

Q9WV27

RefSeq (mRNA)

NM_001001734
NM_144699

NM_013734

RefSeq (protein)

NP_001001734
NP_653300

NP_038762

Location (UCSC)Chr 1: 160.15 – 160.19 MbChr 1: 172.05 – 172.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.[5][6][7]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132681 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007107 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Buetow KH, Nishimura D, Nakamura Y, Jiang O, Murray JC (May 1991). "A detailed multipoint gene map of chromosome 1q". Genomics. 8 (1): 13–21. doi:10.1016/0888-7543(90)90220-O. PMID 1981991.
  6. ^ Shull MM, Lingrel JB (Jul 1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc Natl Acad Sci U S A. 84 (12): 4039–43. Bibcode:1987PNAS...84.4039S. doi:10.1073/pnas.84.12.4039. PMC 305017. PMID 3035563.
  7. ^ a b "Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide".

External links

Further reading

  • Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na, K-ATPase". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 38: 37–89. doi:10.1016/S0079-6603(08)60708-4. ISBN 978-0-12-540038-1. PMID 2158121.
  • Sverdlov ED, Broude NE, Sverdlov VE, et al. (1987). "Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism". FEBS Lett. 221 (1): 129–33. doi:10.1016/0014-5793(87)80366-6. PMID 2887455.
  • Sverdlov ED, Monastyrskaya GS, Broude NE, et al. (1987). "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit". FEBS Lett. 217 (2): 275–8. doi:10.1016/0014-5793(87)80677-4. PMID 3036582.
  • Shamraj OI, Lingrel JB (1995). "A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12952–6. doi:10.1073/pnas.91.26.12952. PMC 45558. PMID 7809153.
  • Woo AL, James PF, Lingrel JB (1999). "Characterization of the fourth alpha isoform of the Na, K-ATPase". J. Membr. Biol. 169 (1): 39–44. doi:10.1007/PL00005899. PMID 10227850. S2CID 838189.
  • Woo AL, James PF, Lingrel JB (2000). "Sperm motility is dependent on a unique isoform of the Na, K-ATPase". J. Biol. Chem. 275 (27): 20693–9. doi:10.1074/jbc.M002323200. PMID 10764792.
  • Woo AL, James PF, Lingrel JB (2003). "Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility". Mol. Reprod. Dev. 62 (3): 348–56. doi:10.1002/mrd.90002. PMID 12112599. S2CID 84176157.
  • Keryanov S, Gardner KL (2002). "Physical mapping and characterization of the human Na, K-ATPase isoform, ATP1A4". Gene. 292 (1–2): 151–66. doi:10.1016/S0378-1119(02)00647-9. PMID 12119109.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lingrel J, Moseley A, Dostanic I, et al. (2003). "Functional roles of the alpha isoforms of the Na, K-ATPase". Ann. N. Y. Acad. Sci. 986 (1): 354–9. Bibcode:2003NYASA.986..354L. doi:10.1111/j.1749-6632.2003.tb07214.x. PMID 12763850. S2CID 81201599.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hlivko JT, Chakraborty S, Hlivko TJ, et al. (2006). "The human Na, K-ATPase alpha 4 isoform is an ouabain-sensitive alpha isoform that is expressed in sperm". Mol. Reprod. Dev. 73 (1): 101–15. doi:10.1002/mrd.20383. PMID 16175638. S2CID 24972193.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Rodova M, Nguyen AN, Blanco G (2006). "The transcription factor CREMtau and cAMP regulate promoter activity of the Na, K-ATPase alpha4 isoform". Mol. Reprod. Dev. 73 (11): 1435–47. doi:10.1002/mrd.20518. PMID 16894555. S2CID 85128131.
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3.6.13.6.23.6.3-4: ATPase
3.6.3
Cu++ (3.6.3.4)
Ca+ (3.6.3.8)
Na+/K+ (3.6.3.9)
H+/K+ (3.6.3.10)
  • ATP4A
Other P-type ATPase
3.6.4
3.6.5: GTPase
3.6.5.1: Heterotrimeric G protein
3.6.5.2: Small GTPase > Ras superfamily
3.6.5.3: Protein-synthesizing GTPase
3.6.5.5-6: Polymerization motors


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