Paramethasone
Chemical compound
- H02AB05 (WHO)
- (6α,11β,16α)-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
- 53-33-8
Y
- 5875
- DB01384
N
- 5664 Y
- VFC6ZX3584
- C07413 N
- ChEMBL1579 Y
- DTXSID3023421
- Interactive image
- O=C\1\C=C/[C@]4(/C(=C/1)[C@@H](F)C[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)[C@@H](C[C@@H]23)C)C)C
InChI
- InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1Y
- Key:MKPDWECBUAZOHP-AFYJWTTESA-NY
N
Y (what is this?) (verify)Paramethasone is a fluorinated glucocorticoid with anti-inflammatory and immunosuppressant properties.[1]
References
- ^ Toxnet: Paramethasone Archived 2019-08-29 at the Wayback Machine
Further reading
- Wershil BK, Furuta GT, Lavigne JA, Choudhury AR, Wang ZS, Galli SJ (1995). "Dexamethasone and cyclosporin A suppress mast cell-leukocyte cytokine cascades by multiple mechanisms". International Archives of Allergy and Immunology. 107 (1–3): 323–4. doi:10.1159/000237015. PMID 7613160.
- Riccardi C, Cifone MG, Migliorati G (December 1999). "Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes". Cell Death and Differentiation. 6 (12): 1182–9. doi:10.1038/sj.cdd.4400609. PMID 10637434.
- Lavista Llanos S, Roldán A (April 1999). "Effect of dexamethasone on nitric oxide (NO.) production by cultured astrocytes". Biocell. 23 (1): 29–35. PMID 10904533.
- v
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| Natural | |
|---|---|
| Synthetic |
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- Antagonists: Aglepristone
- Ketoconazole
- Mifepristone
- Ulipristal acetate
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
- See also
- Glucocorticoid receptor modulators
- Mineralocorticoids and antimineralocorticoids
- List of corticosteroids
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