Prorenoic acid

Chemical compound
Prorenoic acid
Clinical data
Other namesProrenoate; 6α,7α-Dihydro-17-hydroxy-3-oxo-3'H-cyclopropa(6,7)-17α-pregna-4,6-diene-21-carboxylic acid
Drug classAntimineralocorticoid
Identifiers
  • 3-[(1R,2R,4R,10R,11S,14S,15R,18S)-15-Hydroxy-10,14-dimethyl-7-oxopentacyclo[9.7.0.02,4.05,10.014,18]octadec-5-en-15-yl]propanoate
CAS Number
  • 49848-01-3 checkY
UNII
  • WET36J3301
CompTox Dashboard (EPA)
  • DTXSID401023631 Edit this at Wikidata
Chemical and physical data
FormulaC23H31O4
Molar mass371.497 g·mol−1
3D model (JSmol)
  • Interactive image
  • O([H])[C@](CCC(=O)[O-])1CC[C@@]([H])2[C@]1(C)CC[C@@]([H])1[C@](C)3CCC(C=C3[C@@]([H])3C[C@]3([H])[C@@]21[H])=O
InChI
  • InChI=1S/C23H32O4/c1-21-7-3-13(24)11-18(21)14-12-15(14)20-16(21)4-8-22(2)17(20)5-9-23(22,27)10-6-19(25)26/h11,14-17,20,27H,3-10,12H2,1-2H3,(H,25,26)/p-1/t14-,15+,16+,17+,20-,21-,22+,23-/m1/s1
  • Key:OHZWNMVYJJTNKU-VAFIVCJBSA-M

Prorenoic acid, or prorenoate, is a synthetic steroidal antimineralocorticoid which was never marketed.[1][2][3][4]

See also

  • Prorenoate potassium
  • Prorenone

References

  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1036–. ISBN 978-1-4757-2085-3.
  2. ^ Claire M, Rafestin-Oblin ME, Michaud A, Roth-Meyer C, Corvol P (April 1979). "Mechanism of action of a new antialdosterone compound, prorenone". Endocrinology. 104 (4): 1194–1200. doi:10.1210/endo-104-4-1194. PMID 436757.
  3. ^ Netchitailo P, Delarue C, Perroteau I, Jegou S, Tonon MC, Leroux P, et al. (February 1982). "Effect of aldosterone antagonists on mineralocorticoid synthesis in vitro. Inhibition of aldosterone production by prorenoate-K". European Journal of Pharmacology. 77 (4): 243–249. doi:10.1016/0014-2999(82)90125-x. PMID 6277668.
  4. ^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 234–. ISBN 978-94-011-4439-1.
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Mineralocorticoid receptor modulators
MRTooltip Mineralocorticoid receptor
Agonists
Antagonists
See also
Receptor/signaling modulators
Mineralocorticoids and antimineralocorticoids
Glucocorticoid receptor modulators
List of corticosteroids
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