SYT9

Protein-coding gene in the species Homo sapiens
SYT9
Identifiers
AliasesSYT9, synaptotagmin 9
External IDsOMIM: 613528 MGI: 1926373 HomoloGene: 11062 GeneCards: SYT9
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SYT9
Genomic location for SYT9
Band11p15.4Start7,238,778 bp[1]
End7,469,043 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SYT9
Genomic location for SYT9
Band7|7 E3Start106,969,935 bp[2]
End107,147,863 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • internal globus pallidus

  • cerebellar vermis

  • corpus callosum

  • subthalamic nucleus

  • cerebellar hemisphere

  • inferior ganglion of vagus nerve

  • external globus pallidus

  • ventral tegmental area

  • medulla oblongata

  • pons
Top expressed in
  • habenula

  • medial dorsal nucleus

  • medial geniculate nucleus

  • molar

  • lateral geniculate nucleus

  • cerebellar vermis

  • superior cervical ganglion

  • ventromedial nucleus

  • mammillary body

  • iris
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium-dependent phospholipid binding
  • metal ion binding
  • clathrin binding
  • calcium ion binding
  • syntaxin binding
  • identical protein binding
  • phosphatidylserine binding
  • phosphatidylinositol-4,5-bisphosphate binding
  • SNARE binding
Cellular component
  • cytoplasmic vesicle
  • integral component of membrane
  • cell junction
  • synapse
  • dense core granule
  • synaptic vesicle membrane
  • secretory granule membrane
  • membrane
  • secretory granule
  • plasma membrane
  • clathrin-coated vesicle membrane
  • integral component of synaptic vesicle membrane
  • hippocampal mossy fiber to CA3 synapse
  • exocytic vesicle
Biological process
  • regulation of insulin secretion
  • positive regulation of calcium ion-dependent exocytosis
  • regulation of calcium ion-dependent exocytosis
  • vesicle fusion
  • calcium ion-regulated exocytosis of neurotransmitter
  • membrane organization
  • calcium-dependent activation of synaptic vesicle fusion
  • regulation of dopamine secretion
  • synaptic vesicle exocytosis
  • vesicle-mediated transport
  • calcium-ion regulated exocytosis
  • cellular response to calcium ion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

143425

60510

Ensembl

ENSG00000170743

ENSMUSG00000062542

UniProt

Q86SS6

Q9R0N9

RefSeq (mRNA)

NM_175733

NM_021889

RefSeq (protein)

NP_783860

NP_068689

Location (UCSC)Chr 11: 7.24 – 7.47 MbChr 7: 106.97 – 107.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptotagmin-9 is a protein that in humans is encoded by the SYT9 gene.[5][6]

Interactions

SYT9 has been shown to interact with SYNCRIP,[7] TUBB[8] and TRPV1.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170743 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062542 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Craxton M (Sep 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
  6. ^ "Entrez Gene: SYT9 synaptotagmin IX".
  7. ^ Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
  8. ^ Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.
  9. ^ Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.

Further reading

  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.
  • Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.

\* Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430. S2CID 84792445.

  • Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF (May 2002). "Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis". Neuron. 34 (4): 599–611. doi:10.1016/S0896-6273(02)00671-2. PMID 12062043. S2CID 16768299.
  • Fukuda M, Kowalchyk JA, Zhang X, Martin TF, Mikoshiba K (Feb 2002). "Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells". The Journal of Biological Chemistry. 277 (7): 4601–4. doi:10.1074/jbc.C100588200. PMID 11751925.
  • Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
  • Perin MS (Oct 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
  • v
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  • e
Synaptic vesicle
SNARE
Q-SNARE
R-SNARE
Synaptotagmin
Other
COPICOPIIRME/Clathrin
CaveolaeOther/ungrouped
Vesicle formation
Adaptor protein complex 1:
Adaptor protein complex 2:
Adaptor protein complex 3:
Adaptor protein complex 4:
BLOC-1:
BLOC-2:
BLOC-3:
Coats:
Small GTPase
Other
See also vesicular transport protein disorders


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