VAMP3

VAMP3
Identifiers
Aliases	VAMP3, CEB, vesicle associated membrane protein 3
External IDs	OMIM: 603657; MGI: 1321389; HomoloGene: 3511; GeneCards: VAMP3; OMA:VAMP3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 7,771,296 bp[1] End 7,781,432 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 151,131,757 bp[2] End 151,142,420 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior olivary nucleus parietal pleura visceral pleura optic nerve gingival epithelium inferior ganglion of vagus nerve dorsal motor nucleus of vagus nerve C1 segment palpebral conjunctiva trabecular bone Top expressed in endothelial cell of lymphatic vessel ciliary body primitive streak iris retinal pigment epithelium conjunctival fornix epithelium of lens stroma of bone marrow Paneth cell epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNAP receptor activity protein binding SNARE binding syntaxin-1 binding Cellular component integral component of membrane recycling endosome cytosol intracellular membrane-bounded organelle membrane synapse intracellular anatomical structure secretory granule cell surface cell junction SNARE complex apical plasma membrane intracellular organelle neuron projection cytoplasmic vesicle clathrin-coated vesicle trans-Golgi network membrane transport vesicle plasma membrane clathrin-coated vesicle membrane phagocytic vesicle membrane perinuclear region of cytoplasm recycling endosome membrane phagocytic vesicle integral component of synaptic vesicle membrane Biological process Golgi to plasma membrane protein transport mucus secretion regulation of histamine secretion by mast cell membrane fusion vesicle docking involved in exocytosis retrograde transport, endosome to Golgi negative regulation of secretion by cell protein transport substrate adhesion-dependent cell spreading vesicle fusion vesicle-mediated transport calcium-ion regulated exocytosis positive regulation of receptor recycling exocytosis SNARE complex assembly antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent membrane organization cellular response to interferon-gamma protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9341 22319 Ensembl ENSG00000049245 ENSMUSG00000028955 UniProt Q15836 Q6FGG2 P63024 RefSeq (mRNA) NM_004781 NM_009498 RefSeq (protein) NP_004772 NP_004772.1 NP_033524 Location (UCSC) Chr 1: 7.77 – 7.78 Mb Chr 4: 151.13 – 151.14 Mb PubMed search [3] [4]
Wikidata
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Vesicle-associated membrane protein 3 is a protein that in humans is encoded by the VAMP3 gene.^[5][6]

Function

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.^[6]

Interactions

VAMP3 has been shown to interact with

• BCAP31,^[7]
• BVES,^[8]
• SNAP23,^[9][10][11]
• STX4,^{[9][10][12][13]}
• STX6.^[14]

References

Further reading