TUBGCP2

Protein-coding gene in the species Homo sapiens
TUBGCP2
Identifiers
AliasesTUBGCP2, GCP-2, GCP2, Grip103, SPBC97, Spc97p, h103p, hGCP2, hSpc97, tubulin gamma complex associated protein 2, ALP4, SPC97, PAMDDFS
External IDsOMIM: 617817; MGI: 1921487; HomoloGene: 55980; GeneCards: TUBGCP2; OMA:TUBGCP2 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for TUBGCP2
Genomic location for TUBGCP2
Band10q26.3Start133,278,635 bp[1]
End133,318,823 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for TUBGCP2
Genomic location for TUBGCP2
Band7|7 F4Start139,575,868 bp[2]
End139,616,582 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • skin of abdomen

  • anterior pituitary

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • left uterine tube

  • spleen

  • right lung

  • canal of the cervix

  • tibial nerve
Top expressed in
  • spermatocyte

  • seminiferous tubule

  • maxillary prominence

  • spermatid

  • somite

  • autopod region

  • hand

  • dermis

  • foot

  • abdominal wall
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • structural constituent of cytoskeleton
  • protein binding
  • microtubule minus-end binding
  • gamma-tubulin binding
Cellular component
  • cytoplasm
  • cytosol
  • centrosome
  • spindle pole
  • equatorial microtubule organizing center
  • membrane
  • nucleoplasm
  • microtubule organizing center
  • gamma-tubulin small complex
  • spindle pole body
  • cytoplasmic microtubule
  • cytoskeleton
  • microtubule
  • gamma-tubulin complex
Biological process
  • centrosome duplication
  • microtubule nucleation by interphase microtubule organizing center
  • mitotic spindle assembly
  • cytoplasmic microtubule organization
  • microtubule cytoskeleton organization
  • microtubule nucleation
  • meiosis
  • mitotic cell cycle
  • spindle assembly
  • protein-containing complex assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10844

74237

Ensembl

ENSG00000130640

ENSMUSG00000025474

UniProt

Q9BSJ2

Q921G8

RefSeq (mRNA)

NM_001256617
NM_001256618
NM_006659

NM_001286007
NM_001286009
NM_001286011
NM_133755

RefSeq (protein)

NP_001243546
NP_001243547
NP_006650

NP_001272936
NP_001272938
NP_001272940
NP_598516

Location (UCSC)Chr 10: 133.28 – 133.32 MbChr 7: 139.58 – 139.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene.[5][6] It is part of the gamma-tubulin complex, which is required for microtubule nucleation at the centrosome.

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130640 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025474 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Murphy SM, Urbani L, Stearns T (Jun 1998). "The Mammalian γ-Tubulin Complex Contains Homologues of the Yeast Spindle Pole Body Components Spc97p and Spc98p". J Cell Biol. 141 (3): 663–74. doi:10.1083/jcb.141.3.663. PMC 2132743. PMID 9566967.
  6. ^ "Entrez Gene: TUBGCP2 tubulin, gamma complex associated protein 2".

Further reading

  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Takahashi M, Yamagiwa A, Nishimura T, et al. (2003). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
  • Murphy SM, Preble AM, Patel UK, et al. (2002). "GCP5 and GCP6: Two New Members of the Human γ-Tubulin Complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.


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