TUBGCP3

Protein-coding gene in the species Homo sapiens
TUBGCP3
Identifiers
AliasesTUBGCP3, 104p, GCP3, Grip104, SPBC98, Spc98, Spc98p, tubulin gamma complex associated protein 3, ALP6
External IDsOMIM: 617818; MGI: 2183752; HomoloGene: 4609; GeneCards: TUBGCP3; OMA:TUBGCP3 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for TUBGCP3
Genomic location for TUBGCP3
Band13q34Start112,485,011 bp[1]
End112,588,205 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for TUBGCP3
Genomic location for TUBGCP3
Band8|8 A1.1Start12,664,277 bp[2]
End12,722,248 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • bone marrow cells

  • ganglionic eminence

  • gastric mucosa

  • tibial nerve

  • right lobe of liver

  • skin of abdomen

  • appendix

  • canal of the cervix

  • left uterine tube
Top expressed in
  • thymus

  • cerebellar cortex

  • superior frontal gyrus

  • dorsomedial hypothalamic nucleus

  • dermis

  • neural tube

  • medullary collecting duct

  • ganglionic eminence

  • yolk sac

  • ventromedial nucleus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • structural molecule activity
  • structural constituent of cytoskeleton
  • protein binding
  • microtubule minus-end binding
  • gamma-tubulin binding
Cellular component
  • cytoplasm
  • cytosol
  • centrosome
  • spindle pole
  • equatorial microtubule organizing center
  • membrane
  • spindle
  • microtubule organizing center
  • gamma-tubulin small complex
  • polar microtubule
  • spindle pole body
  • centriole
  • cytoskeleton
  • microtubule
  • gamma-tubulin complex
Biological process
  • centrosome duplication
  • microtubule nucleation by interphase microtubule organizing center
  • single fertilization
  • mitotic spindle assembly
  • cytoplasmic microtubule organization
  • microtubule cytoskeleton organization
  • microtubule nucleation
  • meiosis
  • mitotic cell cycle
  • spindle assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10426

259279

Ensembl

ENSG00000282003
ENSG00000126216

ENSMUSG00000000759

UniProt

Q96CW5

P58854

RefSeq (mRNA)

NM_001286277
NM_001286278
NM_001286279
NM_006322

NM_198031

RefSeq (protein)

NP_001273206
NP_001273207
NP_001273208
NP_006313

NP_932148

Location (UCSC)Chr 13: 112.49 – 112.59 MbChr 8: 12.66 – 12.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-tubulin complex component 3 is a protein that in humans is encoded by the TUBGCP3 gene.[5][6][7] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

See also

References

  1. ^ a b c ENSG00000126216 GRCh38: Ensembl release 89: ENSG00000282003, ENSG00000126216 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000759 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Murphy SM, Urbani L, Stearns T (Jun 1998). "The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p". J Cell Biol. 141 (3): 663–74. doi:10.1083/jcb.141.3.663. PMC 2132743. PMID 9566967.
  6. ^ Tassin AM, Celati C, Moudjou M, Bornens M (Jun 1998). "Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin". J Cell Biol. 141 (3): 689–701. doi:10.1083/jcb.141.3.689. PMC 2132749. PMID 9566969.
  7. ^ "Entrez Gene: TUBGCP3 tubulin, gamma complex associated protein 3".

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Takahashi M, Yamagiwa A, Nishimura T, et al. (2003). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
  • Murphy SM, Preble AM, Patel UK, et al. (2002). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.


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