Gemopatrilat

Chemical compound
  • None
Identifiers
  • (6S)-Hexahydro-6-[(αS)-α-mercaptohydrocinnamido]-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid
CAS Number
  • 160135-92-2
PubChem CID
  • 9886079
ChemSpider
  • 8061752
UNII
  • MU9089C77W
KEGG
  • D04312
ChEMBL
  • ChEMBL107747
CompTox Dashboard (EPA)
  • DTXSID901029484 Edit this at Wikidata
Chemical and physical dataFormulaC19H26N2O4SMolar mass378.49 g·mol−13D model (JSmol)
  • Interactive image
  • CC1(CCC[C@@H](C(=O)N1CC(=O)O)NC(=O)[C@H](CC2=CC=CC=C2)S)C
InChI
  • InChI=1S/C19H26N2O4S/c1-19(2)10-6-9-14(18(25)21(19)12-16(22)23)20-17(24)15(26)11-13-7-4-3-5-8-13/h3-5,7-8,14-15,26H,6,9-12H2,1-2H3,(H,20,24)(H,22,23)/t14-,15-/m0/s1
  • Key:YRSVDSQRGBYVIY-GJZGRUSLSA-N

Gemopatrilat (INN)[1] is an experimental drug that was never marketed.[2] It acts as a vasopeptidase inhibitor.[3][4] It inhibits both angiotensin-converting enzyme (ACE) and neutral endopeptidase (neprilysin).[5]

References

  1. ^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 46" (PDF). World Health Organization. p. 200. Retrieved 2 March 2017.
  2. ^ "Gemopatrilat". AdisInsight. Highest Development Phases: Discontinued
  3. ^ Laverman GD, Van Goor H, Henning RH, De Jong PE, De Zeeuw D, Navis G (January 2003). "Renoprotective effects of VPI versus ACEI in normotensive nephrotic rats on different sodium intakes". Kidney International. 63 (1): 64–71. doi:10.1046/j.1523-1755.2003.00708.x. PMID 12472769.
  4. ^ Wait JC, Vaccharajani N, Mitroka J, Jemal M, Khan S, Bonacorsi SJ, et al. (June 2006). "Metabolism of [14C]gemopatrilat after oral administration to rats, dogs, and humans". Drug Metabolism and Disposition. 34 (6): 961–70. doi:10.1124/dmd.105.007500. PMID 16540589. S2CID 25629874.
  5. ^ Hubner RA, Kubota E, Casley DJ, Johnston CI, Burrell LM (May 2001). "In-vitro and in-vivo inhibition of rat neutral endopeptidase and angiotensin converting enzyme with the vasopeptidase inhibitor gemopatrilat". Journal of Hypertension. 19 (5): 941–6. doi:10.1097/00004872-200105000-00015. PMID 11393678. S2CID 9162678.
  • v
  • t
  • e
Antihypertensive drugs acting on the renin–angiotensin system (C09)
ACE inhibitors
("-pril")AIIRAs
("-sartan")Renin inhibitors
("-kiren")Dual ACE/NEP inhibitors
Neprilysin inhibitors
  • v
  • t
  • e
ATRTooltip Angiotensin receptor
Combinations:
Stub icon

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e