MS4A3

Protein-coding gene in the species Homo sapiens

MS4A3

Identifiers

Aliases

MS4A3, CD20L, HTM4, membrane spanning 4-domains A3

External IDs

OMIM: 606498; MGI: 2158468; HomoloGene: 4472; GeneCards: MS4A3; OMA:MS4A3 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q12.1	Start	60,056,587 bp^[1]
Band	11q12.1	End	60,071,115 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	11,606,860 bp^[2]
Band	19\|19 A	End	11,618,215 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bone marrow

bone marrow cells

monocyte

blood

spleen

right lung

placenta

appendix

upper lobe of left lung

gallbladder

Top expressed in

bone marrow

right ventricle

body of femur

olfactory epithelium

medial ganglionic eminence

spleen

cochlea

sexually immature organism

carotid body

digastric muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	cytoplasm perinuclear region of cytoplasm integral component of membrane membrane endomembrane system plasma membrane specific granule membrane
Biological process	regulation of cell cycle neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


932


170813

Ensembl


ENSG00000149516 ENSG00000284903


ENSMUSG00000024681

UniProt


Q96HJ5


Q920C4

RefSeq (mRNA)


NM_001031666 NM_001031809 NM_006138


NM_133246

RefSeq (protein)


NP_001026836 NP_001026979 NP_006129


NP_573509

Location (UCSC)

Chr 11: 60.06 – 60.07 Mb

Chr 19: 11.61 – 11.62 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene.^[5]^[6]

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.^[6]

Interactions

MS4A3 has been shown to interact with CDKN3.^[7]

References

^ ^a ^b ^c ENSG00000284903 GRCh38: Ensembl release 89: ENSG00000149516, ENSG00000284903 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024681 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adra CN, Lelias JM, Kobayashi H, Kaghad M, Morrison P, Rowley JD, Lim B (Nov 1994). "Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions". Proc Natl Acad Sci U S A. 91 (21): 10178–82. Bibcode:1994PNAS...9110178A. doi:10.1073/pnas.91.21.10178. PMC 44981. PMID 7524084.
^ ^a ^b "Entrez Gene: MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)".
^ Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1). United States: 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Chinami M, Yano Y, Yang X, et al. (2005). "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2". J. Biol. Chem. 280 (17): 17235–42. doi:10.1074/jbc.M413437200. PMID 15671017.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Donato JL, Ko J, Kutok JL, et al. (2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1): 51–8. doi:10.1172/JCI14025. PMC 150822. PMID 11781350.
Liang Y, Buckley TR, Tu L, et al. (2001). "Structural organization of the human MS4A gene cluster on Chromosome 11q12". Immunogenetics. 53 (5): 357–68. doi:10.1007/s002510100339. PMID 11486273. S2CID 21846867.
Liang Y, Tedder TF (2001). "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse". Genomics. 72 (2): 119–27. doi:10.1006/geno.2000.6472. PMID 11401424.