TSPAN8

Protein-coding gene in humans

TSPAN8

Identifiers

Aliases

TSPAN8, CO-029, TM4SF3, tetraspanin 8

External IDs

OMIM: 600769 MGI: 2384918 HomoloGene: 20968 GeneCards: TSPAN8

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q21.1	Start	71,125,085 bp^[1]
Band	12q21.1	End	71,441,898 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 D2	Start	115,652,737 bp^[2]
Band	10\|10 D2	End	115,685,798 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

jejunal mucosa

rectum

duodenum

pancreatic ductal cell

bronchial epithelial cell

gallbladder

pylorus

spinal ganglia

appendix

islet of Langerhans

Top expressed in

seminal vesicula

mucous cell of stomach

epithelium of stomach

left colon

pyloric antrum

crypt of lieberkuhn of small intestine

Paneth cell

right lung lobe

ileum

left lung lobe

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	integrin binding protein binding
Cellular component	integral component of membrane integral component of plasma membrane extracellular exosome membrane cell surface
Biological process	cell surface receptor signaling pathway negative regulation of blood coagulation spermatogenesis regulation of gene expression
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7103


216350

Ensembl


ENSG00000127324


ENSMUSG00000034127

UniProt


P19075


Q8R3G9

RefSeq (mRNA)


NM_004616 NM_001369760


NM_001168679 NM_001168680 NM_146010

RefSeq (protein)


NP_004607 NP_001356689


NP_001162150 NP_001162151 NP_666122

Location (UCSC)

Chr 12: 71.13 – 71.44 Mb

Chr 10: 115.65 – 115.69 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.^[6]

Clinical significance

Overall survival of ovarian cancer patients was effectively predicted by TSPAN8.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127324 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034127 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (September 1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6833–7. Bibcode:1990PNAS...87.6833S. doi:10.1073/pnas.87.17.6833. PMC 54632. PMID 2395876.
^ ^a ^b "Entrez Gene: TSPAN8 tetraspanin 8".
^ Fekete T, Rásó E, Pete I, Tegze B, Liko I, Munkácsy G, Sipos N, Rigó J, Györffy B (July 2012). "Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples" (PDF). International Journal of Cancer. 131 (1): 95–105. doi:10.1002/ijc.26364. PMID 21858809. S2CID 205944534.

Berditchevski F (December 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Gwynn B, Eicher EM, Peters LL (July 1996). "Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome". Genomics. 35 (2): 389–91. doi:10.1006/geno.1996.0375. PMID 8661157.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E (May 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 ( Pt 1) (Pt 1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
Kanetaka K, Sakamoto M, Yamamoto Y, Yamasaki S, Lanza F, Kanematsu T, Hirohashi S (November 2001). "Overexpression of tetraspanin CO-029 in hepatocellular carcinoma". Journal of Hepatology. 35 (5): 637–42. doi:10.1016/S0168-8278(01)00183-0. PMID 11690710.
Shackel NA, McGuinness PH, Abbott CA, Gorrell MD, McCaughan GW (September 2003). "Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization". Hepatology. 38 (3): 577–88. doi:10.1053/jhep.2003.50376. PMID 12939584. S2CID 46013740.
Kuhn S, Koch M, Nübel T, Ladwein M, Antolovic D, Klingbeil P, Hildebrand D, Moldenhauer G, Langbein L, Franke WW, Weitz J, Zöller M (June 2007). "A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression". Molecular Cancer Research. 5 (6): 553–67. doi:10.1158/1541-7786.MCR-06-0384. PMID 17579117.