TSPAN31

Protein-coding gene in humans
TSPAN31
Identifiers
AliasesTSPAN31, SAS, tetraspanin 31
External IDsOMIM: 181035 MGI: 1914375 HomoloGene: 4359 GeneCards: TSPAN31
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for TSPAN31
Genomic location for TSPAN31
Band12q14.1Start57,738,013 bp[1]
End57,750,219 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for TSPAN31
Genomic location for TSPAN31
Band10|10 D3Start126,903,149 bp[2]
End126,906,133 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic ductal cell

  • islet of Langerhans

  • pericardium

  • right lobe of thyroid gland

  • right adrenal gland

  • corpus epididymis

  • endothelial cell

  • renal medulla

  • gallbladder

  • trigeminal ganglion
Top expressed in
  • left lobe of liver

  • medullary collecting duct

  • renal corpuscle

  • calvaria

  • cumulus cell

  • medial ganglionic eminence

  • molar

  • vas deferens

  • aortic valve

  • epithelium of stomach
More reference expression data
BioGPS


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6302

67125

Ensembl

ENSG00000135452

ENSMUSG00000006736

UniProt

Q12999

Q9CQ88

RefSeq (mRNA)

NM_005981
NM_001330168
NM_001330169

NM_025982

RefSeq (protein)

NP_001317097
NP_001317098
NP_005972

NP_080258

Location (UCSC)Chr 12: 57.74 – 57.75 MbChr 10: 126.9 – 126.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tetraspanin-31 is a protein that in humans is encoded by the TSPAN31 gene.[5]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135452 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006736 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TSPAN31 tetraspanin 31".

Further reading

  • Wright MD, Tomlinson MG (1995). "The ins and outs of the transmembrane 4 superfamily". Immunol. Today. 15 (12): 588–94. doi:10.1016/0167-5699(94)90222-4. PMID 7531445.
  • Meltzer PS, Jankowski SA, Dal Cin P, et al. (1992). "Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors". Cell Growth Differ. 2 (10): 495–501. PMID 1661131.
  • Jankowski SA, De Jong P, Meltzer PS (1995). "Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas". Genomics. 25 (2): 501–6. doi:10.1016/0888-7543(95)80051-M. PMID 7789984.
  • Jankowski SA, Mitchell DS, Smith SH, et al. (1994). "SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins". Oncogene. 9 (4): 1205–11. PMID 8134123.
  • Elkahloun AG, Krizman DB, Wang Z, et al. (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers". Genomics. 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.
  • Wunder JS, Eppert K, Burrow SR, et al. (1999). "Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas". Oncogene. 18 (3): 783–8. doi:10.1038/sj.onc.1202346. PMID 9989829.
  • Ragazzini P, Gamberi G, Benassi MS, et al. (1999). "Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma". Cancer Detect. Prev. 23 (2): 129–36. doi:10.1046/j.1525-1500.1999.09907.x. PMID 10101594.
  • Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Ragazzini P, Gamberi G, Pazzaglia L, et al. (2004). "Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma". Histol. Histopathol. 19 (2): 401–11. PMID 15024701.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • v
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ArrestinMembrane-spanning 4A
  • MS4A1
  • MS4A2
  • MS4A3
  • MS4A4A
  • MS4A4E
  • MS4A5
  • MS4A6A
  • MS4A6E
  • MS4A7
  • MS4A8B
  • MS4A9
  • MS4A10
  • MS4A12
  • MS4A13
  • MS4A14
  • MS4A15
  • MS4A18
MyelinPulmonary surfactantTetraspanin
Other/ungrouped
see also other cell membrane protein disorders


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