EEF1D

Protein-coding gene in the species Homo sapiens
EEF1D
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2MVM, 2MVN, 2N51

Identifiers
AliasesEEF1D, EF-1D, EF1D, FP1047, eukaryotic translation elongation factor 1 delta
External IDsOMIM: 130592; MGI: 1913906; HomoloGene: 23404; GeneCards: EEF1D; OMA:EEF1D - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for EEF1D
Genomic location for EEF1D
Band8q24.3Start143,579,697 bp[1]
End143,599,541 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for EEF1D
Genomic location for EEF1D
Band15|15 D3Start75,766,054 bp[2]
End75,781,405 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • apex of heart

  • left ovary

  • right ovary

  • body of pancreas

  • right lobe of thyroid gland

  • prostate

  • muscle layer of sigmoid colon

  • body of uterus

  • canal of the cervix
Top expressed in
  • primitive streak

  • condyle

  • fossa

  • internal carotid artery

  • somite

  • endothelial cell of lymphatic vessel

  • aortic valve

  • ascending aorta

  • external carotid artery

  • hair follicle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • heat shock protein binding
  • translation factor activity, RNA binding
  • signal transducer activity
  • translation elongation factor activity
  • protein binding
  • cadherin binding
Cellular component
  • cytoplasm
  • endoplasmic reticulum
  • nucleus
  • eukaryotic translation elongation factor 1 complex
  • fibrillar center
  • cytosol
Biological process
  • regulation of transcription, DNA-templated
  • regulation of cell death
  • translational elongation
  • mRNA transcription
  • transcription, DNA-templated
  • cellular response to ionizing radiation
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • signal transduction
  • protein biosynthesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1936

66656

Ensembl

ENSG00000104529
ENSG00000273594

ENSMUSG00000055762

UniProt

P29692

P57776

RefSeq (mRNA)
NM_001130053
NM_001130054
NM_001130055
NM_001130056
NM_001130057

NM_001195203
NM_001289950
NM_001960
NM_032378
NM_001317743
NM_001330646

NM_001285429
NM_001285430
NM_001285431
NM_001285432
NM_001285433

NM_001285434
NM_023240
NM_029663

RefSeq (protein)
NP_001123525
NP_001123527
NP_001123528
NP_001123529
NP_001182132

NP_001276879
NP_001304672
NP_001317575
NP_001951
NP_115754

NP_001272358
NP_001272359
NP_001272360
NP_001272361
NP_001272362

NP_001272363
NP_075729
NP_083939

Location (UCSC)Chr 8: 143.58 – 143.6 MbChr 15: 75.77 – 75.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Elongation factor 1-delta is a protein that in humans is encoded by the EEF1D gene.[5]

Function

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs. Several alternatively spliced transcript variants have been found for this gene, however, the full length nature of only two variants has been determined.[6]

Interactions

EEF1D has been shown to interact with Glycyl-tRNA synthetase,[7] EEF1G[8][9] and KTN1,[10] and is predicted to interact with TMEM63A.[11]

References

  1. ^ a b c ENSG00000273594 GRCh38: Ensembl release 89: ENSG00000104529, ENSG00000273594 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055762 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sanders J, Raggiaschi R, Morales J, Möller W (Jul 1993). "The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1174 (1): 87–90. doi:10.1016/0167-4781(93)90097-W. PMID 8334168.
  6. ^ "Entrez Gene: EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)".
  7. ^ Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
  8. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  9. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  10. ^ Ong LL, Er CP, Ho A, Aung MT, Yu H (Aug 2003). "Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum". The Journal of Biological Chemistry. 278 (34): 32115–23. doi:10.1074/jbc.M210917200. PMID 12773547.
  11. ^ "String Database". Retrieved 16 May 2014.

Further reading

  • Venema RC, Peters HI, Traugh JA (Jul 1991). "Phosphorylation of elongation factor 1 (EF-1) and valyl-tRNA synthetase by protein kinase C and stimulation of EF-1 activity". The Journal of Biological Chemistry. 266 (19): 12574–80. doi:10.1016/S0021-9258(18)98937-4. PMID 2061327.
  • van Damme HT, Amons R, Karssies R, Timmers CJ, Janssen GM, Möller W (Aug 1990). "Elongation factor 1 beta of artemia: localization of functional sites and homology to elongation factor 1 delta". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1050 (1–3): 241–7. doi:10.1016/0167-4781(90)90174-z. PMID 2207149.
  • Bec G, Kerjan P, Zha XD, Waller JP (Dec 1989). "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1". The Journal of Biological Chemistry. 264 (35): 21131–7. doi:10.1016/S0021-9258(19)30056-0. PMID 2556394.
  • Wolfson AD, Orlovsky AF, Gladilin KL (Oct 1988). "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor". FEBS Letters. 238 (2): 262–4. doi:10.1016/0014-5793(88)80492-7. PMID 3169261. S2CID 45934458.
  • Mulner-Lorillon O, Minella O, Cormier P, Capony JP, Cavadore JC, Morales J, Poulhe R, Bellé R (Aug 1994). "Elongation factor EF-1 delta, a new target for maturation-promoting factor in Xenopus oocytes". The Journal of Biological Chemistry. 269 (31): 20201–7. doi:10.1016/S0021-9258(17)32146-4. PMID 8051108.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Bec G, Kerjan P, Waller JP (Jan 1994). "Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation". The Journal of Biological Chemistry. 269 (3): 2086–92. doi:10.1016/S0021-9258(17)42139-9. PMID 8294461.
  • Sanders J, Brandsma M, Janssen GM, Dijk J, Möller W (May 1996). "Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum". Journal of Cell Science. 109 (5): 1113–7. doi:10.1242/jcs.109.5.1113. PMID 8743958.
  • Chang YW, Traugh JA (Nov 1997). "Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation". The Journal of Biological Chemistry. 272 (45): 28252–7. doi:10.1074/jbc.272.45.28252. PMID 9353277.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Sheu GT, Traugh JA (Dec 1997). "Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli. Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII". The Journal of Biological Chemistry. 272 (52): 33290–7. doi:10.1074/jbc.272.52.33290. PMID 9407120.
  • Xiao H, Neuveut C, Benkirane M, Jeang KT (Mar 1998). "Interaction of the second coding exon of Tat with human EF-1 delta delineates a mechanism for HIV-1-mediated shut-off of host mRNA translation". Biochemical and Biophysical Research Communications. 244 (2): 384–9. doi:10.1006/bbrc.1998.8274. PMID 9514931.
  • Kolettas E, Lymboura M, Khazaie K, Luqmani Y (1998). "Modulation of elongation factor-1 delta (EF-1 delta) expression by oncogenes in human epithelial cells". Anticancer Research. 18 (1A): 385–92. PMID 9568107.
  • Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721. S2CID 916155.
  • Chacko G, Ling Q, Hajjar KA (Jul 1998). "Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta". The Journal of Biological Chemistry. 273 (31): 19840–6. doi:10.1074/jbc.273.31.19840. PMID 9677419.
  • Sheu GT, Traugh JA (Jan 1999). "A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII". Molecular and Cellular Biochemistry. 191 (1–2): 181–6. doi:10.1023/A:1006802125856. PMID 10094407. S2CID 775166.
  • Furusawa T, Moribe H, Kondoh H, Higashi Y (Dec 1999). "Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1". Molecular and Cellular Biology. 19 (12): 8581–90. doi:10.1128/mcb.19.12.8581. PMC 84984. PMID 10567582.
  • Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
  • Lei YX, Chen JK, Wu ZL (2002). "Blocking the translation elongation factor-1 delta with its antisense mRNA results in a significant reversal of its oncogenic potential". Teratogenesis, Carcinogenesis, and Mutagenesis. 22 (5): 377–83. doi:10.1002/tcm.10034. PMID 12210501.
  • v
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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts


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