EIF3M

Protein-coding gene in the species Homo sapiens
EIF3M
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3J8B, 3J8C, 5A5T

Identifiers
AliasesEIF3M, B5, PCID1, TANGO7, hfl-B5, GA17, eukaryotic translation initiation factor 3 subunit M
External IDsOMIM: 609641; MGI: 1351744; HomoloGene: 4639; GeneCards: EIF3M; OMA:EIF3M - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for EIF3M
Genomic location for EIF3M
Band11p13Start32,583,798 bp[1]
End32,606,264 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for EIF3M
Genomic location for EIF3M
Band2 E2|2 55.06 cMStart104,830,001 bp[2]
End104,847,425 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • germinal epithelium

  • superficial temporal artery

  • parietal pleura

  • body of pancreas

  • ganglionic eminence

  • left ovary

  • oral cavity

  • monocyte

  • epithelium of nasopharynx

  • endometrium
Top expressed in
  • epiblast

  • ovary

  • pancreas

  • embryo

  • ventricular zone

  • ganglionic eminence

  • embryo

  • islet of Langerhans

  • uterus

  • spermatocyte
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • translation initiation factor binding
  • protein binding
  • translation initiation factor activity
Cellular component
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • cytosol
  • eukaryotic translation initiation factor 3 complex, eIF3m
  • eukaryotic 43S preinitiation complex
  • eukaryotic 48S preinitiation complex
Biological process
  • translational initiation
  • cytoplasmic translational initiation
  • protein biosynthesis
  • formation of cytoplasmic translation initiation complex
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10480

98221

Ensembl

ENSG00000149100

ENSMUSG00000027170

UniProt

Q7L2H7

Q99JX4

RefSeq (mRNA)

NM_001307929
NM_006360

NM_145380

RefSeq (protein)

NP_001294858
NP_006351

NP_663355

Location (UCSC)Chr 11: 32.58 – 32.61 MbChr 2: 104.83 – 104.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 3, subunit M (eIF3m) also known as PCI domain containing 1 (herpesvirus entry mediator) (PCID1), is a protein that in humans is encoded by the EIF3M gene.[5][6]

HFLB5 encodes a broadly expressed protein containing putative membrane fusion domains that acts as a receptor or coreceptor for entry of herpes simplex virus (HSV).[5][7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149100 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027170 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PCID1 PCI domain containing 1 (herpesvirus entry mediator)".
  6. ^ Gawin B, Niederführ A, Schumacher N, Hummerich H, Little PF, Gessler M (November 1999). "A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1". Genome Res. 9 (11): 1074–86. doi:10.1101/gr.9.11.1074. PMC 310838. PMID 10568747.
  7. ^ Perez A, Li QX, Perez-Romero P, Delassus G, Lopez SR, Sutter S, McLaren N, Fuller AO (June 2005). "A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins". J. Virol. 79 (12): 7419–30. doi:10.1128/JVI.79.12.7419-7430.2005. PMC 1143644. PMID 15919898.

Further reading

  • Kobayashi K, Xin Y, Ymer SI, et al. (2007). "Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells". Brain Res. 1170: 129–39. doi:10.1016/j.brainres.2007.07.042. PMID 17719568. S2CID 31320196.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Perez-Romero P, Fuller AO (2005). "The C terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection". J. Virol. 79 (12): 7431–7. doi:10.1128/JVI.79.12.7431-7437.2005. PMC 1143627. PMID 15919899.
  • Perez A, Li QX, Perez-Romero P, et al. (2005). "A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins". J. Virol. 79 (12): 7419–30. doi:10.1128/JVI.79.12.7419-7430.2005. PMC 1143644. PMID 15919898.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q7L2H7 (Eukaryotic translation initiation factor 3 subunit M) at the PDBe-KB.
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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts


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