Mitochondrial ribosomal protein L39

Protein-coding gene in the species Homo sapiens
MRPL39
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3J7Y, 3J9M

Identifiers
AliasesMRPL39, C21orf92, L39mt, MRP-L5, MRPL5, PRED22, PRED66, RPML5, MSTP003, mitochondrial ribosomal protein L39, L5mt
External IDsOMIM: 611845; MGI: 1351620; HomoloGene: 9679; GeneCards: MRPL39; OMA:MRPL39 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for MRPL39
Genomic location for MRPL39
Band21q21.3Start25,585,656 bp[1]
End25,607,517 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for MRPL39
Genomic location for MRPL39
Band16|16 C3.3Start84,514,464 bp[2]
End84,532,630 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • tendon of biceps brachii

  • left ventricle

  • right adrenal gland

  • Achilles tendon

  • right adrenal cortex

  • gastrocnemius muscle

  • secondary oocyte

  • muscle of thigh

  • left testis
Top expressed in
  • fossa

  • condyle

  • seminiferous tubule

  • facial motor nucleus

  • motor neuron

  • right ventricle

  • primitive streak

  • Paneth cell

  • medial ganglionic eminence

  • hair follicle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • RNA binding
Cellular component
  • mitochondrial inner membrane
  • ribosome
  • mitochondrial ribosome
  • mitochondrial large ribosomal subunit
  • mitochondrion
Biological process
  • mitochondrial translational elongation
  • mitochondrial translational termination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54148

27393

Ensembl

ENSG00000154719

ENSMUSG00000022889

UniProt

Q9NYK5

Q9JKF7

RefSeq (mRNA)

NM_017446
NM_080794

NM_017404
NM_001384093
NM_001384095
NM_001384096

RefSeq (protein)

NP_059142
NP_542984

NP_059100
NP_001371022
NP_001371024
NP_001371025

Location (UCSC)Chr 21: 25.59 – 25.61 MbChr 16: 84.51 – 84.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L39, mitochondrial is a protein that in humans is encoded by the MRPL39 gene.[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154719 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022889 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  6. ^ a b "Entrez Gene: MRPL39 mitochondrial ribosomal protein L39".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • O'Brien TW, Fiesler SE, Denslow ND, et al. (2000). "Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 274 (51): 36043–51. doi:10.1074/jbc.274.51.36043. PMID 10593885.
  • Spirina O, Bykhovskaya Y, Kajava AV, et al. (2001). "Heart-specific splice-variant of a human mitochondrial ribosomal protein (mRNA processing; tissue specific splicing)". Gene. 261 (2): 229–34. doi:10.1016/S0378-1119(00)00504-7. PMID 11167009.
  • O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease". Gene. 286 (1): 73–9. doi:10.1016/S0378-1119(01)00808-3. PMID 11943462.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
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