CREBL1

Protein-coding gene in the species Homo sapiens
ATF6B
Identifiers
AliasesATF6B, CREB-RP, CREBL1, G13, activating transcription factor 6 beta
External IDsOMIM: 600984; MGI: 105121; HomoloGene: 31238; GeneCards: ATF6B; OMA:ATF6B - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ATF6B
Genomic location for ATF6B
Band6p21.32Start32,115,264 bp[1]
End32,128,253 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for ATF6B
Genomic location for ATF6B
Band17 B1|17 18.22 cMStart34,866,120 bp[2]
End34,874,048 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • right uterine tube

  • right lobe of thyroid gland

  • spleen

  • left lobe of thyroid gland

  • gallbladder

  • canal of the cervix

  • pituitary gland

  • lymph node

  • appendix
Top expressed in
  • yolk sac

  • lip

  • neural tube

  • thymus

  • entorhinal cortex

  • superior frontal gyrus

  • ganglionic eminence

  • external carotid artery

  • ascending aorta

  • cerebellar cortex
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • DNA-binding transcription factor activity
  • protein binding
  • cAMP response element binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • endoplasmic reticulum membrane
  • membrane
  • intracellular anatomical structure
  • integral component of endoplasmic reticulum membrane
  • protein-DNA complex
  • endoplasmic reticulum
  • nucleus
  • endomembrane system
  • nucleolus
  • RNA polymerase II transcription regulator complex
Biological process
  • regulation of transcription, DNA-templated
  • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
  • regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • endoplasmic reticulum unfolded protein response
  • ATF6-mediated unfolded protein response
  • response to unfolded protein
  • signal transduction
  • transcription by RNA polymerase II
  • positive regulation of transcription by RNA polymerase II
  • negative regulation of ATF6-mediated unfolded protein response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1388

12915

Ensembl

ENSG00000213676
ENSG00000228628
ENSG00000234539
ENSG00000168468

ENSMUSG00000015461

UniProt

Q99941

O35451

RefSeq (mRNA)

NM_004381
NM_001136153

NM_017406

RefSeq (protein)

NP_001129625
NP_004372

n/a

Location (UCSC)Chr 6: 32.12 – 32.13 MbChr 17: 34.87 – 34.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CAMP responsive element binding protein-like 1, also known as CREBL1, is a protein which in humans is encoded by the CREBL1 gene.[5][6]

Function

The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.[5]

References

  1. ^ a b c ENSG00000228628, ENSG00000234539, ENSG00000168468 GRCh38: Ensembl release 89: ENSG00000213676, ENSG00000228628, ENSG00000234539, ENSG00000168468 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015461 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CREBL1 cAMP responsive element binding protein-like 1".
  6. ^ Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, Mori K (April 2001). "Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response". Biochem. J. 355 (Pt 1): 19–28. doi:10.1042/0264-6021:3550019. PMC 1221707. PMID 11256944.

Further reading

  • Bristow J, Tee MK, Gitelman SE, et al. (1993). "Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B". J. Cell Biol. 122 (1): 265–78. doi:10.1083/jcb.122.1.265. PMC 2119596. PMID 7686164.
  • Min J, Shukla H, Kozono H, et al. (1996). "A novel Creb family gene telomeric of HLA-DRA in the HLA complex". Genomics. 30 (2): 149–56. doi:10.1006/geno.1995.9891. PMID 8586413.
  • Khanna A, Campbell RD (1996). "The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein". Biochem. J. 319. ( Pt 1) (Pt 1): 81–9. doi:10.1042/bj3190081. PMC 1217738. PMID 8870652.
  • Speek M, Barry F, Miller WL (1997). "Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes". Hum. Mol. Genet. 5 (11): 1749–58. doi:10.1093/hmg/5.11.1749. PMID 8923003.
  • Swanson DJ, Adachi M, Lewis EJ (2000). "The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein". J. Biol. Chem. 275 (4): 2911–23. doi:10.1074/jbc.275.4.2911. PMID 10644760.
  • Yoshida H, Okada T, Haze K, et al. (2001). "Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response". Mol. Cell. Biol. 21 (4): 1239–48. doi:10.1128/MCB.21.4.1239-1248.2001. PMC 99577. PMID 11158310.
  • Ye J, Rawson RB, Komuro R, et al. (2001). "ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs". Mol. Cell. 6 (6): 1355–64. doi:10.1016/S1097-2765(00)00133-7. PMID 11163209.
  • Haze K, Okada T, Yoshida H, et al. (2001). "Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response". Biochem. J. 355 (Pt 1): 19–28. doi:10.1042/0264-6021:3550019. PMC 1221707. PMID 11256944.
  • Tong WY, Nagano-Fujii M, Hidajat R, et al. (2003). "Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta" (PDF). Biochem. Biophys. Res. Commun. 299 (3): 366–72. doi:10.1016/S0006-291X(02)02638-4. PMID 12445808. Archived from the original (PDF) on 2020-07-12. Retrieved 2020-09-05.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Okada T, Haze K, Nadanaka S, et al. (2003). "A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6". J. Biol. Chem. 278 (33): 31024–32. doi:10.1074/jbc.M300923200. PMID 12782636.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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